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JAK inhibitor exposure affects response to ritlecitinib for alopecia areata

19 Nov 2025

In patients with alopecia areata who received treatment with ritlecitinib, prior exposure to Janus kinase inhibitors is associated with reduced early response, reveals a study.

JAK inhibitor exposure affects response to ritlecitinib for alopecia areata

19 Nov 2025

Does antibiotic use prevent wound complications in episiotomy, second-degree tear?

19 Nov 2025 by

The use of prophylactic antibiotics shows no significant impact on overall wound complication but leads to a significant risk reduction in clinically relevant wound complications among women with episiotomies and second-degree tears, reports a study.

Does antibiotic use prevent wound complications in episiotomy, second-degree tear?

19 Nov 2025

Is high-dose IV push levetiracetam safe to administer?

19 Nov 2025

A recent study has provided further evidence on the safety and tolerability of rapid administration of undiluted levetiracetam, including 2,500- and 4,500-mg doses.

Is high-dose IV push levetiracetam safe to administer?

19 Nov 2025

High-dose flu vaccine extends benefit to adults aged 50–64 years

19 Nov 2025 by

A modified double-blind study shows the immunological superiority of high-dose (HD) over standard-dose (SD) inactivated influenza vaccine (IIV) in adults aged 50–64 years.

High-dose flu vaccine extends benefit to adults aged 50–64 years

19 Nov 2025

Acute kidney injury in preemies tied to poor neurodevelopmental outcomes

19 Nov 2025

Preterm infants with acute kidney injury (AKI) may have poor neurodevelopmental outcomes, according to a study.

Acute kidney injury in preemies tied to poor neurodevelopmental outcomes

19 Nov 2025

Enfortumab vedotin plus pembrolizumab confers survival benefit in MIBC

19 Nov 2025 by

Adding perioperative enfortumab vedotin and pembrolizumab (EV + pembro) to surgery with radical cystectomy plus standard pelvic lymph node dissection (RC + PLND) significantly improves event-free survival (EFS) and overall survival (OS) in patients with muscle-invasive bladder cancer (MIBC) who are ineligible for cisplatin-based therapy, based on the first interim analysis of the phase III KEYNOTE-905 study presented at ESMO 2025.

Enfortumab vedotin plus pembrolizumab confers survival benefit in MIBC

19 Nov 2025

Fixed-dose 4F-PCC safe, effective for FXal reversal in non-neurologic bleeds

18 Nov 2025

A fixed-dose four-factor prothrombin complex concentrate (4F-PCC) demonstrates both safety and efficacy for factor Xa inhibitor (FXal) reversal in patients with non-neurologic haemorrhage, according to a recent study.

Fixed-dose 4F-PCC safe, effective for FXal reversal in non-neurologic bleeds

18 Nov 2025

Updated CNS tumour epidemiology in Southeast Asia may guide future studies

18 Nov 2025 by

A study in Singapore has provided a comprehensive update of the epidemiology of brain and spinal tumours managed surgically, helping guide future research on central nervous system (CNS) tumours.

Updated CNS tumour epidemiology in Southeast Asia may guide future studies

18 Nov 2025

Accumulated daily steps in longer bouts tied to fewer mortality, CVD events

18 Nov 2025

Daily accumulated steps in longer bouts appear to result in lower mortality and cardiovascular disease (CVD) risks than steps accumulated in shorter bouts among suboptimally active adults, reveals a study.

Accumulated daily steps in longer bouts tied to fewer mortality, CVD events

18 Nov 2025

Kidney stone history linked to poor survival outcomes in upper tract urothelial carcinoma

18 Nov 2025

Among patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy, those with a history of urinary tract stones appear to have poorer cancer-specific survival (CSS) and disease-free survival (DFS), according to a study.

Kidney stone history linked to poor survival outcomes in upper tract urothelial carcinoma

18 Nov 2025

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JAK inhibitor exposure affects response to ritlecitinib for alopecia areata

JAK inhibitor exposure affects response to ritlecitinib for alopecia areata

Does antibiotic use prevent wound complications in episiotomy, second-degree tear?

Does antibiotic use prevent wound complications in episiotomy, second-degree tear?

Is high-dose IV push levetiracetam safe to administer?

Is high-dose IV push levetiracetam safe to administer?

High-dose flu vaccine extends benefit to adults aged 50–64 years

High-dose flu vaccine extends benefit to adults aged 50–64 years

Acute kidney injury in preemies tied to poor neurodevelopmental outcomes

Acute kidney injury in preemies tied to poor neurodevelopmental outcomes

Enfortumab vedotin plus pembrolizumab confers survival benefit in MIBC

Enfortumab vedotin plus pembrolizumab confers survival benefit in MIBC

Fixed-dose 4F-PCC safe, effective for FXal reversal in non-neurologic bleeds

Fixed-dose 4F-PCC safe, effective for FXal reversal in non-neurologic bleeds

Updated CNS tumour epidemiology in Southeast Asia may guide future studies

Updated CNS tumour epidemiology in Southeast Asia may guide future studies

Accumulated daily steps in longer bouts tied to fewer mortality, CVD events

Accumulated daily steps in longer bouts tied to fewer mortality, CVD events

Kidney stone history linked to poor survival outcomes in upper tract urothelial carcinoma

Kidney stone history linked to poor survival outcomes in upper tract urothelial carcinoma