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Inhaled sedation with sevoflurane not beneficial in moderate-to-severe ARDS

29 May 2025

In critically ill patients with moderate-to-severe acute respiratory distress syndrome (ARDS), inhaled sedation with sevoflurane may lead to fewer ventilator-free days at day 28 and lower 90-day survival compared with sedation with propofol, according to the results of the phase III SESAR study.

Inhaled sedation with sevoflurane not beneficial in moderate-to-severe ARDS

29 May 2025

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-May-2025

29 May 2025

New drug applications approved by US FDA as of 1-15 May 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-May-2025

29 May 2025

β-lactam/β-lactamase inhibitor combination noninferior to piperacillin/tazobactam for pneumonia

28 May 2025

In the treatment of adults with hospital-associated (HABP) or ventilator-associated bacterial pneumonia (VABP), the β-lactam/β-lactamase inhibitor combination imipenem/cilastatin/relebactam appears to be as good as piperacillin/tazobactam, with similar safety profiles, according to a phase III trial.

β-lactam/β-lactamase inhibitor combination noninferior to piperacillin/tazobactam for pneumonia

28 May 2025

High, increasing BMI ups risk of adulthood OSA

26 May 2025 by

Individuals with high or continuously increasing BMI from childhood to middle age are at greater risk of developing obstructive sleep apnoea (OSA) later in life, reveals a study.

High, increasing BMI ups risk of adulthood OSA

26 May 2025

Personalizing upfront treatment options for advanced EGFRm NSCLC

26 May 2025 by

This article will summarize the latest developments in the first-line management of advanced EGFRm NSCLC and highlight key consideration factors.

Personalizing upfront treatment options for advanced EGFRm NSCLC

26 May 2025

VMR tied to severe COPD exacerbation

25 May 2025

Visceral fat-to-muscle ratio (VMR) can be used to predict the severe exacerbation of chronic obstructive pulmonary disease (COPD), suggests a study.

VMR tied to severe COPD exacerbation

25 May 2025

$Achieving remission with anti–IL-5 therapy in a patient with adult-onset asthma and refractory EGPA$

Achieving remission with anti–IL-5 therapy in a patient with adult-onset asthma and refractory EGPA

24 May 2025 by

A 57-year-old lady presented in January 2015 with bilateral lower limb numbness, vasculitic rash over her lower limb, shortness of breath, and sudden loss of vision in her left eye. She had a history of adult-onset asthma for more than 10 years (managed with inhaled corticosteroids and bronchodilator), and had two episodes of exacerbation 6 months before presentation. Other comorbidities included allergic rhinitis and paroxysmal atrial fibrillation.

Achieving remission with anti–IL-5 therapy in a patient with adult-onset asthma and refractory EGPA

24 May 2025

TrUST study heralds new era for TB diagnosis

21 May 2025 by

A suite of deep learning (DL) models to automate tuberculosis (TB) risk assessment from lung ultrasound (LUS) images fulfils the WHO criteria for a sputum-free TB triage test and outwits human experts in the TrUST study.

TrUST study heralds new era for TB diagnosis

21 May 2025

Dual therapy as good as three-drug HIV regimen in patients coinfected with TB

19 May 2025 by

In the treatment of HIV in individuals who are receiving rifampin-based therapy for tuberculosis, a two-drug antiretroviral (ART) regimen comprising double-dose dolutegravir plus lamivudine compares favourably with a three-drug regimen of efavirenz, tenofovir, and lamivudine in terms of suppressing viral load, as shown in a study.

Dual therapy as good as three-drug HIV regimen in patients coinfected with TB

19 May 2025

Meta-analysis strengthens case for awake prone positioning in COVID-19 with AHRF

17 May 2025 by

Placing awake COVID-19 patients with acute hypoxaemic respiratory failure (AHRF) in a prone position is an efficacious intervention in terms of both reducing mortality and preventing intubation, according to an individual participant data meta-analysis.

Meta-analysis strengthens case for awake prone positioning in COVID-19 with AHRF

17 May 2025

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Inhaled sedation with sevoflurane not beneficial in moderate-to-severe ARDS

Inhaled sedation with sevoflurane not beneficial in moderate-to-severe ARDS

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-May-2025

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-May-2025

β-lactam/β-lactamase inhibitor combination noninferior to piperacillin/tazobactam for pneumonia

β-lactam/β-lactamase inhibitor combination noninferior to piperacillin/tazobactam for pneumonia

High, increasing BMI ups risk of adulthood OSA

High, increasing BMI ups risk of adulthood OSA

Personalizing upfront treatment options for advanced EGFRm NSCLC

Personalizing upfront treatment options for advanced EGFRm NSCLC

VMR tied to severe COPD exacerbation

VMR tied to severe COPD exacerbation

Achieving remission with anti–IL-5 therapy in a patient with adult-onset asthma and refractory EGPA

Achieving remission with anti–IL-5 therapy in a patient with adult-onset asthma and refractory EGPA

TrUST study heralds new era for TB diagnosis

TrUST study heralds new era for TB diagnosis

Dual therapy as good as three-drug HIV regimen in patients coinfected with TB

Dual therapy as good as three-drug HIV regimen in patients coinfected with TB

Meta-analysis strengthens case for awake prone positioning in COVID-19 with AHRF

Meta-analysis strengthens case for awake prone positioning in COVID-19 with AHRF