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EPIK-B5 supports alpelisib plus fulvestrant for HR+, HER2– ABC

15 Jan 2026 by

In the phase III EPIK-B5 study, adding alpelisib, an α-specific PI3K inhibitor, to fulvestrant improves progression-free survival (PFS) in men and postmenopausal women with HR+, HER2− advanced breast cancer (ABC) harbouring a PIK3CA mutation who have progressed on or after treatment with an aromatase inhibitor (AI) and a CDK4/6 inhibitor (CDK4/6i).

EPIK-B5 supports alpelisib plus fulvestrant for HR+, HER2– ABC

15 Jan 2026

Risk-reducing bilateral mastectomy confers survival benefit in BRCA carriers

15 Jan 2026

Risk-reducing bilateral mastectomy in patients with the BRCA pathogenic variant appears to be associated with lower overall and breast-cancer specific mortality, according to a meta-analysis.

Risk-reducing bilateral mastectomy confers survival benefit in BRCA carriers

15 Jan 2026

Frontline anlotinib-containing regimen shows promise in advanced soft-tissue sarcoma

14 Jan 2026

In the treatment of patients with advanced soft-tissue sarcoma, combining anlotinib with anthracyclines and ifosfamide in the first-line setting followed by anlotinib maintenance has demonstrated promising efficacy, with acceptable toxicities, in a phase II study.

Frontline anlotinib-containing regimen shows promise in advanced soft-tissue sarcoma

14 Jan 2026

Children conceived via ART at increased risk of atopic disease

14 Jan 2026 by

New research shows that children born via assisted reproductive technology (ART) are prone to developing asthma, allergic rhinitis, or atopic dermatitis.

Children conceived via ART at increased risk of atopic disease

14 Jan 2026

Patients with JIA suffer poorer HRQOL than RA, general populations

14 Jan 2026

Health-related quality of life (HRQOL) is lower in patients with juvenile idiopathic arthritis (JIA) than those with rheumatoid arthritis (RA) and the general population 6 months following the initiation of disease-modifying antirheumatic drug (DMARD) treatment, reveals a study. Both patient groups, however, enjoy similar improvement levels with treatment.

Patients with JIA suffer poorer HRQOL than RA, general populations

14 Jan 2026

Novel syringe improves HCP experience during aspiration

14 Jan 2026 by

A novel syringe demonstrates better user experience than a hypodermic syringe during aspiration by standardizing the process, regardless of user, drug type, volume, or injection site, reports a study.

Novel syringe improves HCP experience during aspiration

14 Jan 2026

Human milk composition tied to maternal overweight/obesity, low supply

14 Jan 2026

Maternal overweight/obesity (OW) can alter the composition of human milk (HM) and affect infant milk intake, suggests a study.

Human milk composition tied to maternal overweight/obesity, low supply

14 Jan 2026

Children with repaired CHD have impaired cardiorespiratory fitness

14 Jan 2026 by

Children with surgically corrected congenital heart disease (CHD) have a significantly reduced cardiorespiratory fitness (CRF) compared with controls in a meta-analysis and meta-regression.

Children with repaired CHD have impaired cardiorespiratory fitness

14 Jan 2026

Z-drug exposure during early pregnancy not a risk factor for congenital malformations

14 Jan 2026

The use of nonbenzodiazepine sedative hypnotics (Z-drugs) for sleep dysregulation during the first trimester of pregnancy does not appear to contribute to a meaningful increase in the risk of congenital malformations overall, as shown in a study.

Z-drug exposure during early pregnancy not a risk factor for congenital malformations

14 Jan 2026

CHD subtypes linked to increased risk of low Apgar scores in newborns

14 Jan 2026 by

According to a study, several congenital heart defect (CHD) subtypes are associated with an elevated risk of low Apgar scores at 5 mins after birth in newborns.

CHD subtypes linked to increased risk of low Apgar scores in newborns

14 Jan 2026

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EPIK-B5 supports alpelisib plus fulvestrant for HR+, HER2– ABC

EPIK-B5 supports alpelisib plus fulvestrant for HR+, HER2– ABC

Risk-reducing bilateral mastectomy confers survival benefit in BRCA carriers

Risk-reducing bilateral mastectomy confers survival benefit in BRCA carriers

Frontline anlotinib-containing regimen shows promise in advanced soft-tissue sarcoma

Frontline anlotinib-containing regimen shows promise in advanced soft-tissue sarcoma

Children conceived via ART at increased risk of atopic disease

Children conceived via ART at increased risk of atopic disease

Patients with JIA suffer poorer HRQOL than RA, general populations

Patients with JIA suffer poorer HRQOL than RA, general populations

Novel syringe improves HCP experience during aspiration

Novel syringe improves HCP experience during aspiration

Human milk composition tied to maternal overweight/obesity, low supply

Human milk composition tied to maternal overweight/obesity, low supply

Children with repaired CHD have impaired cardiorespiratory fitness

Children with repaired CHD have impaired cardiorespiratory fitness

Z-drug exposure during early pregnancy not a risk factor for congenital malformations

Z-drug exposure during early pregnancy not a risk factor for congenital malformations

CHD subtypes linked to increased risk of low Apgar scores in newborns

CHD subtypes linked to increased risk of low Apgar scores in newborns