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CVD tops disease burden, death cause worldwide

CVD tops disease burden, death cause worldwide

11 Dec 2025 byStephen Padilla

The leading cause of disease burden and death across the globe is still cardiovascular disease (CVD), with low, low-middle, and middle sociodemographic index (SDI) regions carrying the heaviest burden, according to a study.

CVD tops disease burden, death cause worldwide

11 Dec 2025
Achieving ultra-low PSA levels with ADT plus ARPI improves mHSPC outcomes in a patient with comorbidities

Achieving ultra-low PSA levels with ADT plus ARPI improves mHSPC outcomes in a patient with comorbidities

11 Dec 2025 byDr. Emerson Kwan-Ho Leung, Specialist in Clinical Oncology, Hong Kong

A 70-year-old male was diagnosed with prostate cancer (PC) after presenting with increased urinary frequency and an elevated prostate-specific antigen (PSA) level of 71 ng/mL in October 2022. (Figure) MRI revealed a 3 cm left prostatic lesion without pelvic lymph node involvement or bone metastases, with possible extra­prostatic extension and seminal vesicle invasion. Transperineal ultrasound-guided prostate biopsy confirmed prostatic ade­nocarcinoma in 8 out of 12 cores, with a Gleason score of 4 + 3. 

Achieving ultra-low PSA levels with ADT plus ARPI improves mHSPC outcomes in a patient with comorbidities

11 Dec 2025