News & Updates

In the 3-year follow-up of the EMPOWER-Lung 1 study, first-line cemiplimab continued to outdo chemotherapy (CT) in providing survival benefit for patients with advanced non-small-cell lung cancer (NSCLC). Moreover, in the second-line setting (patients with progressive disease [PD]), cemiplimab added to CT provided meaningful and durable objective response rate (ORR) and overall survival (OS) benefit.

In a real-world, territory-wide, propensity score (PS)–matched study during Hong Kong’s Omicron BA.2.2 wave, early initiation of molnupiravir or nirmatrelvir/ritonavir is shown to reduce the risks of mortality and in-hospital outcomes among community-dwelling outpatients with COVID-19. However, the risk of hospitalization is lowered with nirmatrelvir/ritonavir but not molnupiravir.

Adults with a high baseline HIV-1 RNA or low CD4 count may benefit from initial treatment with bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), which has been shown to be safe and efficacious over 5 years of follow-up in a study presented at the ID Week 2022 Virtual Conference.

In patients with Clostridioides difficile infections (CDI), treatment with ridinilazole (RDZ) leads to high and sustained rates of clinical response, according to a study presented at the recently concluded Virtual ID Week 2022. Compared with vancomycin (VAN), RDZ also more strongly prevents recurrent CDI (rCDI).

There appears to be several ways to reduce the risk of pre-eclampsia and pregnancy-induced hypertension. These include low molecular weight heparin (LMWH), vitamin D supplementation, calcium supplementation, aspirin, and exercise, according to a meta-analysis.

COVID-19 patients with chronic statin exposure appear to be at lower risk of developing acute kidney injury (AKI) during hospitalization in addition to having reduced levels of inflammation, as reported in a study.

Treatment with the nucleos(t)ide analogue (NUC) tenofovir alafenamide (TAF) for 2 years leads to improvements in liver stiffness among patients with chronic hepatitis B (CHB), including those with advanced liver fibrosis, according to a study presented at the IDWeek 2022 in Washington, DC, US.