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CVD tops disease burden, death cause worldwide
The leading cause of disease burden and death across the globe is still cardiovascular disease (CVD), with low, low-middle, and middle sociodemographic index (SDI) regions carrying the heaviest burden, according to a study.
CVD tops disease burden, death cause worldwide
11 Dec 2025
ICONIC-LEAD affirms oral icotrokinra benefits in plaque psoriasis
In the phase III ICONIC-LEAD trial, selective blockade of the interleukin(IL)-23 receptor with the targeted oral peptide icotrokinra is associated with higher rates of skin clearance and symptom relief in adults and adolescents with moderate-to-severe plaque psoriasis.
ICONIC-LEAD affirms oral icotrokinra benefits in plaque psoriasis
11 Dec 2025
Achieving ultra-low PSA levels with ADT plus ARPI improves mHSPC outcomes in a patient with comorbidities
A 70-year-old male was diagnosed with prostate cancer (PC) after presenting with increased urinary frequency and an elevated prostate-specific antigen (PSA) level of 71 ng/mL in October 2022. (Figure) MRI revealed a 3 cm left prostatic lesion without pelvic lymph node involvement or bone metastases, with possible extraÂprostatic extension and seminal vesicle invasion. Transperineal ultrasound-guided prostate biopsy confirmed prostatic adeÂnocarcinoma in 8 out of 12 cores, with a Gleason score of 4 + 3.






