News &amp; Updates

In patients with obesity but without diabetes, treatment with survodutide results in substantial reductions in body weight compared with placebo, according to the phase III SYNCHRONIZE-1 trial.

Survodutide promotes weight loss in adults with obesity

Venglustat superior to ERT in Gaucher disease type 3

24 Jul 2026 by

Treatment with oral venglustat demonstrates superior neurologic outcomes compared with standard enzyme replacement therapy (ERT) in patients with Gaucher disease type 3 (GD3), according to the phase III LEAP2MONO trial presented at EHA 2026.

Venglustat superior to ERT in Gaucher disease type 3

Real-world ES SCLC outcomes comparable between phase I trial participation and SoC

24 Jul 2026 by

A single-centre retrospective observational study of 90 patients from Australia with extensive-stage small cell lung cancer (SCLC) shows that phase I clinical trial participation has acceptable safety and survival outcomes comparable to those of standard-of-care (SoC) treatment.

Real-world ES SCLC outcomes comparable between phase I trial participation and SoC

24 Jul 2026

Can blood type impact ICI efficacy in head and neck cancer?

24 Jul 2026 by

A multi-omics study by researchers from Japan has found that blood type B (BTB) is associated with reduced immune checkpoint inhibitor (ICI) efficacy in first-line (1L) treatment of head and neck squamous cell carcinoma (HNSCC).

Can blood type impact ICI efficacy in head and neck cancer?

Patients with liver cirrhosis may sleep better with lemborexant

Treatment with lemborexant helps manage sleep disturbances in patients with liver cirrhosis, as shown in the crossover RESTORE trial.

Patients with liver cirrhosis may sleep better with lemborexant

GLP-1RAs up risk for ischaemic optic neuropathy in T2D patients

The use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) results in an increased risk for ischaemic optic neuropathy (ION) at 18 months when compared with the use of sodium‒glucose cotransporter-2 inhibitors (SGLT2is) and dipeptidyl peptidase-4 inhibitors (DPP4is), reports a study.

GLP-1RAs up risk for ischaemic optic neuropathy in T2D patients

Timing of surgery, physiotherapy predict 24-h discharge after TKA

Patients who underwent total knee arthroplasty (TKA) in the morning and received physiotherapy review in the same afternoon have a higher chance of being discharged within 24 h, suggests a Singapore study. This is possible because of early ambulation and adequate time for the spinal anaesthesia to wear off.

Timing of surgery, physiotherapy predict 24-h discharge after TKA

Cumulative LDIR exposure elevates hypertension risk

Constant exposure to occupational low-dose ionizing radiation (LDIR) appears to contribute to hypertension and elevated blood pressure among medical radiologists, with a clear dose-response relationship, suggests a study.

Cumulative LDIR exposure elevates hypertension risk

Mental health literacy rate in SG improving

The second Mind Matters cross-sectional survey conducted in 2023 reports an increase in mental health literacy (MHL) in Singapore since the first survey in 2015.

Mental health literacy rate in SG improving

Optimizing CKD care: Early detection and GDMT improve outcomes

Chronic kidney disease (CKD) is a noncommunicable disease with increasing importance. Its pathophysiology interacts with cardiovascular (CV) and metabolic diseases, and extends to other neurological and respiratory disorders with clinically significant interplay. Despite its growing global burden, CKD remains underdiagnosed and undertreated. At a symposium in Hong Kong, a multidisciplinary panel highlighted the urgent need for earlier identification of CKD, integrated CV-kidney-metabolic (CKM) care, and timely implementation of guideline-directed medical therapy (GDMT) — including sodium-glucose cotransporter-2 inhibitors (SGLT2i; eg, dapagliflozin) — to slow progression toward kidney failure and reduce CKD-related complications.

Optimizing CKD care: Early detection and GDMT improve outcomes