Once-monthly PCSK9 inhibitor in a patient with FH at very high CV risk
25 Jun 2025
byDr. Kin-Ming Tam , Specialist in Cardiology, Private Practice, Hong Kong
A 62-year-old lady first presented on 15 September 2023 with severe chest pain typical of acute coronary syndrome (ACS), pointing to an imminent heart attack. She had been experiencing chest pain and shortness of breath on exertion over the past year, which had worsened in the 3 months prior to presentation, especially when she played tennis. She eventually had to quit all sports activities. The patient did not smoke or drink and had good past health, apart from some renal cysts. She had no history of atherosclerotic cardiovascular disease (ASCVD), but her younger sister suffered acute myocardial infarction (MI) at the age of 51 years, suggesting familial hypercholesterolaemia (FH).
