ESC 2025: Semaglutide cuts MACE risk by 57 percent vs tirzepatide in patients with obesity and ASCVD
03 Oct 2025
byMs. Ms Lauren Wilson, Novo Nordisk, Inc., Plainsboro, New Jersey, US
Compared with tirzepatide, subcutaneous semaglutide 2.4 mg is associated with a 57 percent lower risk of revised 3-point major adverse cardiovascular events (3P-MACE; defined as MI, stroke, and all-cause mortality [instead of cardiovascular-related death]) in a population similar to the SELECT trial — patients with overweight or obesity and established atherosclerotic cardiovascular disease (ASCVD) but no history of diabetes, according to results of the real-world STEER trial presented at the European Society of Cardiology (ESC) Congress 2025.