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PORTEC-3: Adjuvant chemoradiotherapy improves 10-year OS in high-risk endometrial cancer

15 Sep 2025 by

Adjuvant chemoradiotherapy (CRT) improves both 10-year overall survival (OS) and recurrence-free survival (RFS) in women with high-risk endometrial cancer vs pelvic radiotherapy alone, with the most clinically relevant benefit observed in p53 abnormal cancers, according to the 10-year analysis of the phase III PORTEC-3 trial.

PORTEC-3: Adjuvant chemoradiotherapy improves 10-year OS in high-risk endometrial cancer

15 Sep 2025

GLP-1RAs look good for idiopathic intracranial hypertension

14 Sep 2025 by

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) appear promising in the management of idiopathic intracranial hypertension, with a retrospective study showing that the drugs reduce symptom burden as well as the need for medications and invasive procedures.

GLP-1RAs look good for idiopathic intracranial hypertension

14 Sep 2025

Reduced apical rotation linked to functional mitral regurgitation after ST-elevation MI

14 Sep 2025 by

A significant association exists between a reduced apical rotation and functional mitral regurgitation in patients with acute ST-elevation myocardial infarction (MI), suggesting a potential novel pathophysiological mechanism, reports a study.

Reduced apical rotation linked to functional mitral regurgitation after ST-elevation MI

14 Sep 2025

Mepolizumab cuts exposure to OCS in severe eosinophilic asthma

14 Sep 2025

In patients with severe eosinophilic asthma, treatment with mepolizumab reduces exposure to toxic levels of oral corticosteroids (OCS) and, in turn, the incidence of associated complications, according to a real-world study.

Mepolizumab cuts exposure to OCS in severe eosinophilic asthma

14 Sep 2025

Postpartum bleeding lower with prophylactic carbetocin vs oxytocin

13 Sep 2025 by

First-line prophylactic treatment with carbetocin during the third stage of labour works better than oxytocin at reducing the risk of postpartum haemorrhage (PPH), according to a study from Australia.

Postpartum bleeding lower with prophylactic carbetocin vs oxytocin

13 Sep 2025

Does maternal cancer affect offspring development?

13 Sep 2025 by

Children exposed to maternal cancer and its treatment show no significant disruptions in their cardiac, neurocognitive, or physical development during adolescence, reveals a study.

Does maternal cancer affect offspring development?

13 Sep 2025

Routine H pylori screening in acute MI patients of no benefit

13 Sep 2025

Routine screening for Helicobacter pylori infection in patients with acute myocardial infarction (MI) does not help lower the risk of upper gastrointestinal bleeding, according to a crossover trial.

Routine H pylori screening in acute MI patients of no benefit

13 Sep 2025

Being overweight may protect against mortality following surgery in older adults

12 Sep 2025

Among older adults who are undergoing major elective surgery, those who are overweight may have lower mortality after the procedure compared with those who have normal weight, as suggested in a study.

Being overweight may protect against mortality following surgery in older adults

12 Sep 2025

Risk factors for progression in Asians with early-stage CKD identified in study

12 Sep 2025 by

Underlying medical conditions, albuminuria, ethnicity, lifestyle, and medication all factor into the risk of progression in a multiethnic Asian population of patients with early-stage chronic kidney disease (CKD), as shown in a study from Singapore.

Risk factors for progression in Asians with early-stage CKD identified in study

12 Sep 2025

Enzalutamide plus radium-223 improves rPFS in mCRPC

12 Sep 2025 by

First-line treatment with enzalutamide plus radium-223 (Ra223) results in significant improvements in radiological progression-free survival (rPFS) in patients with metastatic castration-resistant prostate cancer (mCRPC), results of the EORTC 1222/PEACE-3 trial have shown.

Enzalutamide plus radium-223 improves rPFS in mCRPC

12 Sep 2025

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PORTEC-3: Adjuvant chemoradiotherapy improves 10-year OS in high-risk endometrial cancer

PORTEC-3: Adjuvant chemoradiotherapy improves 10-year OS in high-risk endometrial cancer

GLP-1RAs look good for idiopathic intracranial hypertension

GLP-1RAs look good for idiopathic intracranial hypertension

Reduced apical rotation linked to functional mitral regurgitation after ST-elevation MI

Reduced apical rotation linked to functional mitral regurgitation after ST-elevation MI

Mepolizumab cuts exposure to OCS in severe eosinophilic asthma

Mepolizumab cuts exposure to OCS in severe eosinophilic asthma

Postpartum bleeding lower with prophylactic carbetocin vs oxytocin

Postpartum bleeding lower with prophylactic carbetocin vs oxytocin

Does maternal cancer affect offspring development?

Does maternal cancer affect offspring development?

Routine H pylori screening in acute MI patients of no benefit

Routine H pylori screening in acute MI patients of no benefit

Being overweight may protect against mortality following surgery in older adults

Being overweight may protect against mortality following surgery in older adults

Risk factors for progression in Asians with early-stage CKD identified in study

Risk factors for progression in Asians with early-stage CKD identified in study

Enzalutamide plus radium-223 improves rPFS in mCRPC

Enzalutamide plus radium-223 improves rPFS in mCRPC