News &amp; Updates

Noncritically ill patients treated with a short course of vancomycin plus piperacillin-tazobactam (VPT) are less likely to experience acute kidney injury (AKI) than those who received an extended course, reports a study.

Short-course vancomycin plus piperacillin-tazobactam tied to fewer AKI incidence

Mitapivat inches its way towards becoming first approved therapy for PK deficiency

22 Dec 2021 by

The investigational pyruvate kinase R (PKR) activator mitapivat continued to show benefit for individuals with PK deficiency (PKD) regardless of transfusion status, according to updated findings from the phase III ACTIVATE trials and the long-term extension (LTE) study.

Mitapivat inches its way towards becoming first approved therapy for PK deficiency

Persistent smoking following surgery for early-stage lung cancer hurts survival

For stage I non-small cell lung cancer (NSCLC) patients who underwent surgery, persistent smoking is detrimental to overall survival, a study has found.

Persistent smoking following surgery for early-stage lung cancer hurts survival

Drinking water may reduce NAFLD prevalence in men

Higher intake of plain water appears to suppress newly diagnosed nonalcoholic fatty liver disease (NAFLD) among men but not women, a recent study has found.

Drinking water may reduce NAFLD prevalence in men

22 Dec 2021

True North: Ozanimod benefits in ulcerative colitis evident in various populations

A post hoc analysis of the phase III True North study showed that the benefits of ozanimod on clinical remission and response in patients with moderate-to-severe ulcerative colitis (UC) as seen in the global analysis were consistent in the analysis of the North American cohort.

True North: Ozanimod benefits in ulcerative colitis evident in various populations

High-soy diets contribute to a long life

Diets high in isoflavones appear to reduce the risk of all-cause mortality among middle-aged adults, reports a recent Japan study.

High-soy diets contribute to a long life

Sleeve gastrectomy vs gastric bypass for weight loss: Which is safer?

Sleeve gastrectomy was associated with a lower risk of mortality and complications over 5 years compared with gastric bypass, although the former intervention comes with an increased risk of surgical revision, reveals a recent study on patients undergoing bariatric surgery for weight loss.

Sleeve gastrectomy vs gastric bypass for weight loss: Which is safer?

Hypotension prevents boosting of sacubitril/valsartan doses for Asians with ACHD-related HF

The angiotensin receptor-neprilysin inhibitors (ARNI) sacubitril/valsartan does not appear to help manage heart failure (HF) in Asian patients with adult congenital heart disease (ACHD), with a small study from Singapore showing that the drug can only be tolerated at suboptimal doses and that hypotension prevents uptitration.

Hypotension prevents boosting of sacubitril/valsartan doses for Asians with ACHD-related HF

Is continuous infusion labetalol haemodynamically safe for type B aortic dissections?

Treatment with high-dose continuous intravenous labetalol (HD-CIVL) results in a nonstatistically significant higher incidence of haemodynamic instability compared to an esmolol combination (EC) regimen in patients with type B aortic dissections (TBADs), results of a study have shown.

Is continuous infusion labetalol haemodynamically safe for type B aortic dissections?

Heart, respiratory rates speed up days before death in cancer patients

Respiratory rate, heart rate, and apnoea counts become more frequent during the last two weeks of life in cancer patients, according to a recent study. Such changes in vital signs may prove valuable for predicting impending death, especially with the help of monitoring devices, though potential modifying effects of opioid use need to be taken into consideration.

Heart, respiratory rates speed up days before death in cancer patients