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AMPLITUDE: Niraparib plus AAP improves survival in mCSPC patients with gene mutations
02 Jul 2025
byStephen Padilla
The combination of niraparib (NIRA) and abiraterone acetate plus prednisone (AAP) results in significant improvements in radiographic progression-free survival (rPFS) and time to symptomatic progression (TSP) in metastatic castration-sensitive prostate cancer (mCSPC) patients with alterations in homologous recombination repair (HRR) genes, as shown by the results of the phase III AMPLITUDE trial.
AMPLITUDE: Niraparib plus AAP improves survival in mCSPC patients with gene mutations
02 Jul 2025
Gemcitabine for IR-NMIBC tied to more recurrence vs BCG
06 Jun 2025
byStephen Padilla
Treatment-naive patients with immediate-risk (IR) nonmuscle-invasive bladder cancer (NMIBC) who received gemcitabine appear to have greater recurrence risk than those given Bacillus Calmette-Guerin (BCG). Both treatments, however, are effective against disease progression.