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AMPLITUDE: Niraparib plus AAP improves survival in mCSPC patients with gene mutations
02 Jul 2025
byStephen Padilla
The combination of niraparib (NIRA) and abiraterone acetate plus prednisone (AAP) results in significant improvements in radiographic progression-free survival (rPFS) and time to symptomatic progression (TSP) in metastatic castration-sensitive prostate cancer (mCSPC) patients with alterations in homologous recombination repair (HRR) genes, as shown by the results of the phase III AMPLITUDE trial.
AMPLITUDE: Niraparib plus AAP improves survival in mCSPC patients with gene mutations
02 Jul 2025
Two-drug combo rises to the challenge as 1L Tx for mTNBC
02 Jul 2025
byAudrey Abella
In the primary analysis of the ASCENT-04/KEYNOTE-D19 study, a combination regimen comprising sacituzumab govitecan (SG) and pembrolizumab delivers significant progression-free survival (PFS) benefit in women with previously untreated PD-L1+ advanced triple-negative breast cancer (TNBC).