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CNS-penetrant oral RIPK1 inhibitor flops for ALS

The selective, oral, central nervous system-penetrant reversible RIPK1 inhibitor SAR443820 appears to have limited clinical benefit in amyotrophic lateral sclerosis (ALS) and is even associated with greater hepatic enzyme increase, according to the phase II HIMALAYA trial.

CNS-penetrant oral RIPK1 inhibitor flops for ALS

5 hours ago

Another oral OX2R agonist for narcolepsy type 1 clears phase II trial

a day ago

The novel oral orexin 2 receptor (OX2R) agonist alixorexton has demonstrated clinical benefits in patients with narcolepsy type 1, yielding improvements in wakefulness, excessive daytime sleepiness, and cataplexy, according to the phase II Vibrance-1 trial.

Another oral OX2R agonist for narcolepsy type 1 clears phase II trial

a day ago

Folic acid may offer protection in ASM-exposed pregnancies

18 Sep 2026 by

Supplementation with high-dose folic acid appears beneficial to pregnant women with epilepsy being treated with antiseizure medications (ASMs), having been associated with a lower incidence of adverse offspring outcomes in an observational study from China.

Folic acid may offer protection in ASM-exposed pregnancies

18 Sep 2026

Perimenopausal sleep disturbances may signal later-life cognitive risk

18 Sep 2026

Sleep disturbances during perimenopause are associated with poorer cognitive function decades later, as suggested in a study.

Perimenopausal sleep disturbances may signal later-life cognitive risk

18 Sep 2026

In utero COVID-19 exposure does not harm early neurodevelopment

17 Sep 2026 by

Children born to mothers with mild or asymptomatic COVID-19 during pregnancy are not at increased risk of neurodevelopmental delay in early life, according a study from Singapore.

In utero COVID-19 exposure does not harm early neurodevelopment

17 Sep 2026

Exoskeleton may provide added gait improvement in subacute stroke patients

16 Sep 2026 by

A study suggests that robot-assisted gait training (RAGT) augmented with a wearable, torque-assisted exoskeleton yields outcomes comparable to conventional gait training (CGT) alone in improving ambulatory function in patients with subacute stroke, with greater gains in lower limb strength.

Exoskeleton may provide added gait improvement in subacute stroke patients

16 Sep 2026

Greater adherence to MIND diet improves global cognition

13 Sep 2026

Higher adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet scores from baseline significantly enhances global cognitive function in community-dwelling adults, a study has shown.

Greater adherence to MIND diet improves global cognition

13 Sep 2026

Fruit, vegetable intake lowers risk of dementia

11 Sep 2026

Consumption of fruits and vegetables may help prevent the development of dementia, suggests a study.

Fruit, vegetable intake lowers risk of dementia

11 Sep 2026

Large study captures risk of poor foetal growth after prenatal antiseizure meds exposure

10 Sep 2026

Prenatal exposure to antiseizure medications is associated with increased risk of poor foetal growth, according to a large prospective study.

Large study captures risk of poor foetal growth after prenatal antiseizure meds exposure

10 Sep 2026

3-week RT helps cut costs in glioblastoma treatment

08 Sep 2026

In older adults with glioblastoma, 3-week radiotherapy (RT) lowers out-of-pocket (OOP) cost by about 5 percent compared with 6-week RT, according to a study.

3-week RT helps cut costs in glioblastoma treatment

08 Sep 2026

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CNS-penetrant oral RIPK1 inhibitor flops for ALS

CNS-penetrant oral RIPK1 inhibitor flops for ALS

Another oral OX2R agonist for narcolepsy type 1 clears phase II trial

Another oral OX2R agonist for narcolepsy type 1 clears phase II trial

Folic acid may offer protection in ASM-exposed pregnancies

Folic acid may offer protection in ASM-exposed pregnancies

Perimenopausal sleep disturbances may signal later-life cognitive risk

Perimenopausal sleep disturbances may signal later-life cognitive risk

In utero COVID-19 exposure does not harm early neurodevelopment

In utero COVID-19 exposure does not harm early neurodevelopment

Exoskeleton may provide added gait improvement in subacute stroke patients

Exoskeleton may provide added gait improvement in subacute stroke patients

Greater adherence to MIND diet improves global cognition

Greater adherence to MIND diet improves global cognition

Fruit, vegetable intake lowers risk of dementia

Fruit, vegetable intake lowers risk of dementia

Large study captures risk of poor foetal growth after prenatal antiseizure meds exposure

Large study captures risk of poor foetal growth after prenatal antiseizure meds exposure

3-week RT helps cut costs in glioblastoma treatment

3-week RT helps cut costs in glioblastoma treatment