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Plug- vs suture-based devices: Which is better for large-bore arterial access closure?

A systematic review and meta-analysis that included 23 studies shows similar safety and efficacy profiles between plug-based vascular closure devices (P-VCDs) and suture-based VCDs (S-VCDs) in large-bore arterial access closure, but the former appears to have an edge over the latter in terms of bleeding events and hospital stay in some of the studies.

Plug- vs suture-based devices: Which is better for large-bore arterial access closure?

a day ago

Tobevibart–elebsiran combo demonstrates therapeutic potential against hepatitis D

a day ago

Patients with chronic hepatitis D virus (HDV) infection appear to respond to treatment with the combination of tobevibart plus elebsiran, according to the phase II, open-label SOLSTICE trial.

Tobevibart–elebsiran combo demonstrates therapeutic potential against hepatitis D

a day ago

Perimenopausal hormonal imbalances drive Alzheimer’s risk, plasma E2:P4 ratio a potential biomarker

09 Dec 2025 by

Researchers from the School of Life Sciences and the Gerald Choa Neuroscience Institute at the Chinese University of Hong Kong (CUHK) have found that estradiol (E2) to progesterone (P4) (E2:P4) imbalance during perimenopause likely increases the risk of Alzheimer’s disease (AD) and AD-related dementia in women via oestrogen-related receptor alpha (ERRα) dysfunction.

Perimenopausal hormonal imbalances drive Alzheimer’s risk, plasma E2:P4 ratio a potential biomarker

09 Dec 2025

Getting physically active in midlife, late life lowers dementia risk

08 Dec 2025 by

Higher levels of physical activity help fight dementia, especially for middle-aged and older adults, according to a study.

Getting physically active in midlife, late life lowers dementia risk

08 Dec 2025

Premotor phase biomarkers may enable early PD diagnosis

08 Dec 2025

Premotor phase biomarkers can be as accurate as motor phase biomarkers in diagnosing Parkinson’s disease (PD), offering an earlier diagnosis compared with clinical methods, suggests a study.

Premotor phase biomarkers may enable early PD diagnosis

08 Dec 2025

Conduct of ward rounds in SG hospitals needs improvement: study

08 Dec 2025 by

Patients in acute care hospitals in Singapore express satisfaction regarding ward round organization and structure. However, the conduct of ward rounds requires further improvement, especially the opportunity for patients to ask questions and the type of information they receive, according to a study.

Conduct of ward rounds in SG hospitals needs improvement: study

08 Dec 2025

Poor sleep quality raises risk of clinical HF

08 Dec 2025

Many women experience poor sleep quality, which is associated with an increased risk of clinical heart failure (HF) and death, reveals a recent study, noting that sleep deprivation may result in worse outcomes in both sexes.

Poor sleep quality raises risk of clinical HF

08 Dec 2025

Night light a CVD risk factor?

08 Dec 2025 by

A prospective cohort study using data from the UK Biobank shows that night light exposure is an important risk factor for adverse cardiovascular (CV) health.

Night light a CVD risk factor?

08 Dec 2025

PPI use hurts survival outcomes in glioblastoma

08 Dec 2025

In patients with newly diagnosed glioblastoma, the use proton pump inhibitors (PPI) may be detrimental to survival, according to a meta-analysis.

PPI use hurts survival outcomes in glioblastoma

08 Dec 2025

CGM cuts hospitalizations due to DKA, severe hypoglycaemia or hyperglycaemia crisis in young diabetes patients

08 Dec 2025 by

Continuous glucose monitoring (CGM) in young diabetes patients not only improves HbA_1c levels, but also substantially reduces hospitalizations due to diabetic ketoacidosis (DKA), severe hypoglycaemia or hyperglycaemia crisis, researchers from the Chinese University of Hong Kong (CUHK) have reported.

CGM cuts hospitalizations due to DKA, severe hypoglycaemia or hyperglycaemia crisis in young diabetes patients

08 Dec 2025

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Plug- vs suture-based devices: Which is better for large-bore arterial access closure?

Plug- vs suture-based devices: Which is better for large-bore arterial access closure?

Tobevibart–elebsiran combo demonstrates therapeutic potential against hepatitis D

Tobevibart–elebsiran combo demonstrates therapeutic potential against hepatitis D

Perimenopausal hormonal imbalances drive Alzheimer’s risk, plasma E2:P4 ratio a potential biomarker

Perimenopausal hormonal imbalances drive Alzheimer’s risk, plasma E2:P4 ratio a potential biomarker

Getting physically active in midlife, late life lowers dementia risk

Getting physically active in midlife, late life lowers dementia risk

Premotor phase biomarkers may enable early PD diagnosis

Premotor phase biomarkers may enable early PD diagnosis

Conduct of ward rounds in SG hospitals needs improvement: study

Conduct of ward rounds in SG hospitals needs improvement: study

Poor sleep quality raises risk of clinical HF

Poor sleep quality raises risk of clinical HF

Night light a CVD risk factor?

Night light a CVD risk factor?

PPI use hurts survival outcomes in glioblastoma

PPI use hurts survival outcomes in glioblastoma

CGM cuts hospitalizations due to DKA, severe hypoglycaemia or hyperglycaemia crisis in young diabetes patients

CGM cuts hospitalizations due to DKA, severe hypoglycaemia or hyperglycaemia crisis in young diabetes patients