News &amp; Updates

For patients who have undergone curative resection for nonmetastatic colorectal cancer (CRC), performing circulating tumour DNA (ctDNA) methylation analysis during surveillance facilitates earlier detection of recurrences suitable for curative therapy, according to interim data from the phase III FIND trial.

CtDNA-guided surveillance catches postoperative CRC recurrences early for curative treatment

01 Sep 2025

Pembrolizumab prolongs real-world survival in NSCLC patients

Treatment with pembrolizumab demonstrates effectiveness in improving progression-free survival (PFS) and overall survival (OS) in real clinical practice, results of a study have shown.

Pembrolizumab prolongs real-world survival in NSCLC patients

CYP3A5-guided tacrolimus dosing tied to faster achievement of target trough levels in kidney recipients

The local ethnic population of kidney transplant recipients in Singapore has a diverse CYP3A5 genotype expression, according to a study. A CYP3A5-guided dosing of tacrolimus may help these patients achieve target trough levels at a faster rate, but it can also put them at greater risk of hyperkalaemia.

CYP3A5-guided tacrolimus dosing tied to faster achievement of target trough levels in kidney recipients

Respiratory virus ups mortality risk in kids undergoing LT

Detection of respiratory viruses in children with severe hepatocellular dysfunction during the peri-liver transplant period appears to increase the risk of death and postoperative surgical complications, reveals a recent study.

Respiratory virus ups mortality risk in kids undergoing LT

Upadacitinib bumps up GCA treatment armamentarium

The primary results of the phase III SELECT-GCA trial underpin the potential of upadacitinib plus a glucocorticoid taper (GC-T) for the treatment of giant-cell arteritis (GCA).

Upadacitinib bumps up GCA treatment armamentarium

Awake craniotomy feasible, safe in patients with drug-resistant focal epilepsy

Performing craniotomy for drug-resistant focal epilepsy while a patient is awake appears feasible and does not increase the risk of adverse events, including intraoperative epileptic seizures, according to a retrospective, single-centre cohort study.

Awake craniotomy feasible, safe in patients with drug-resistant focal epilepsy

Semaglutide 2.4 mg gets US FDA approval for MASH

Subcutaneous (SC) semaglutide 2.4 mg QW is recently granted accelerated approval by the US FDA for treatment of metabolic dysfunction–associated steatohepatitis (MASH) in adults with moderate-to-advanced fibrosis.

Semaglutide 2.4 mg gets US FDA approval for MASH

01 Sep 2025

Morbidity, mortality high in paediatric flu-associated acute necrotizing encephalopathy

Influenza-associated acute necrotizing encephalopathy (ANE) carries increased morbidity and mortality in children, according to a case series.

Morbidity, mortality high in paediatric flu-associated acute necrotizing encephalopathy

SGLT2 inhibitors confer cardiovascular, renal benefits in stage 4 CKM syndrome

31 Aug 2025 by

In the treatment of patients with stage 4 cardiovascular–kidney–metabolic (CKM) syndrome, sodium–glucose cotransporter 2 (SGLT2) inhibitors appear to exert cardio- and renoprotective effects, as shown in a retrospective study.

SGLT2 inhibitors confer cardiovascular, renal benefits in stage 4 CKM syndrome

Flu infection tied to serious complications in children

A recent study has found that influenza virus infection can lead to serious multisystem complications, such as encephalitis and acute respiratory distress syndrome, among others.

Flu infection tied to serious complications in children