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Bexicaserin shows promise in developmental and epileptic encephalopathies

08 Nov 2025

In the treatment of patients with developmental and epileptic encephalopathies (DEEs), the selective serotonin 5-HT2C receptor agonist bexicaserin is well tolerated and appears to reduce the frequency of countable motor seizures, according to a phase Ib/IIa study.

Bexicaserin shows promise in developmental and epileptic encephalopathies

08 Nov 2025

High plasma triglycerides protect patients with PD against cognitive impairment

08 Nov 2025

In patients with Parkinson’s disease (PD), the high risk of mild cognitive impairment (MCI) at the time of diagnosis correlates with low levels of plasma triglycerides (P-TG) and an interaction between change in BMI and P-TG prior to diagnosis, reports a study.

High plasma triglycerides protect patients with PD against cognitive impairment

08 Nov 2025

Retinal ageing marker may predict cognitive decline, dementia

07 Nov 2025 by

A study from Singapore underscores the potential of a retinal ageing biomarker derived from retinal photography as a prognostic biomarker for cognitive decline and incident dementia.

Retinal ageing marker may predict cognitive decline, dementia

07 Nov 2025

Intra-arterial alteplase increases likelihood of excellent post-thrombectomy functional outcome

05 Nov 2025 by

Intra-arterial alteplase (IAA) resulted in a higher likelihood of excellent functional outcome at 90 days among patients with acute, anterior-circulation, large-vessel occlusion (LVO) stroke who achieved successful endovascular reperfusion by mechanical thrombectomy, a study in China has found.

Intra-arterial alteplase increases likelihood of excellent post-thrombectomy functional outcome

05 Nov 2025

Gene variant in Chinese linked to higher Alzheimer’s risk and more severe pathology

05 Nov 2025 by

The TREM2 H157Y variant gene significantly increases the risk of Alzheimer’s disease (AD) in ethnic Chinese and is associated with more rapid clinical progression and more severe neurodegeneration, researchers from the Hong Kong University of Science and Technology (HKUST) have found.

Gene variant in Chinese linked to higher Alzheimer’s risk and more severe pathology

05 Nov 2025

Seizures common in congenital heart disease

03 Nov 2025

Infants appear to have a more than fivefold greater odds of experiencing seizures in the presence of congenital heart disease (CHD), according to a study.

Seizures common in congenital heart disease

03 Nov 2025

High BP harms brain across lifespan

03 Nov 2025

Elevated blood pressure (BP) levels exert a detrimental effect on the brain, and this effect accumulates over a person’s lifetime, as suggested in a study.

High BP harms brain across lifespan

03 Nov 2025

Original New Drug Application Approvals by US FDA (16-30 September 2025)

31 Oct 2025

New drug applications approved by US FDA as of 16-30 September 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16-30 September 2025)

31 Oct 2025

Will ChatGPT pass a neurosurgery board examination?

30 Oct 2025

Neurosurgery residents appear to remain superior to ChatGPT in answering neurosurgery board examination-like questions, suggests a study in the Philippines. However, the studies included in the meta-analysis have high heterogeneity.

Will ChatGPT pass a neurosurgery board examination?

30 Oct 2025

Reducing pharmaceutical sodium content helps manage BP elevations in narcolepsy

29 Oct 2025

In patients with narcolepsy, switching from high- to low-sodium oxybate results in substantial reductions in daily medication-related sodium intake and, in turn, blood pressure levels (BP), according to a study.

Reducing pharmaceutical sodium content helps manage BP elevations in narcolepsy

29 Oct 2025

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Bexicaserin shows promise in developmental and epileptic encephalopathies

Bexicaserin shows promise in developmental and epileptic encephalopathies

High plasma triglycerides protect patients with PD against cognitive impairment

High plasma triglycerides protect patients with PD against cognitive impairment

Retinal ageing marker may predict cognitive decline, dementia

Retinal ageing marker may predict cognitive decline, dementia

Intra-arterial alteplase increases likelihood of excellent post-thrombectomy functional outcome

Intra-arterial alteplase increases likelihood of excellent post-thrombectomy functional outcome

Gene variant in Chinese linked to higher Alzheimer’s risk and more severe pathology

Gene variant in Chinese linked to higher Alzheimer’s risk and more severe pathology

Seizures common in congenital heart disease

Seizures common in congenital heart disease

High BP harms brain across lifespan

High BP harms brain across lifespan

Original New Drug Application Approvals by US FDA (16-30 September 2025)

Original New Drug Application Approvals by US FDA (16-30 September 2025)

Will ChatGPT pass a neurosurgery board examination?

Will ChatGPT pass a neurosurgery board examination?

Reducing pharmaceutical sodium content helps manage BP elevations in narcolepsy

Reducing pharmaceutical sodium content helps manage BP elevations in narcolepsy