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Perimenopausal hormonal imbalances drive Alzheimer’s risk, plasma E2:P4 ratio a potential biomarker

09 Dec 2025 by

Researchers from the School of Life Sciences and the Gerald Choa Neuroscience Institute at the Chinese University of Hong Kong (CUHK) have found that estradiol (E2) to progesterone (P4) (E2:P4) imbalance during perimenopause likely increases the risk of Alzheimer’s disease (AD) and AD-related dementia in women via oestrogen-related receptor alpha (ERRα) dysfunction.

Perimenopausal hormonal imbalances drive Alzheimer’s risk, plasma E2:P4 ratio a potential biomarker

09 Dec 2025

Oral triterpenoid antifungal works against recurrent vulvovaginal candidiasis

07 Dec 2025 by

Treatment with the first-in-class oral nonazole, triterpenoid antifungal ibrexafungerp appears to be efficacious and well-tolerated in patients with recurrent vulvovaginal candidiasis, as shown in the phase III CANDLE study.

Oral triterpenoid antifungal works against recurrent vulvovaginal candidiasis

07 Dec 2025

Oral corticosteroids confer little to no GDM risk for expectant mothers

05 Dec 2025 by

Exposure to oral corticosteroids during pregnancy is not associated with the risk of gestational diabetes mellitus (GDM), except for a modest increase during an early exposure window, as shown in a study from South Korea.

Oral corticosteroids confer little to no GDM risk for expectant mothers

05 Dec 2025

In-utero exposure to INSTI-based ART regimens not a hazard to infant neurodevelopment

05 Dec 2025

Infants exposed to antiretroviral treatment (ART) regimens containing integrase strand transfer inhibitors (INSTIs) in utero seem to fare as well as their nonexposed peers in terms of neurodevelopment, as reported in a study.

In-utero exposure to INSTI-based ART regimens not a hazard to infant neurodevelopment

05 Dec 2025

Does aspirin use worsen IBD severity in pregnant women?

04 Dec 2025

The use of aspirin among pregnant patients with inflammatory bowel disease (IBD) does not appear to increase the risk of disease severity, reports a study. Low-dose aspirin (LDA) has been prescribed to nearly a third of IBD patients during pregnancy.

Does aspirin use worsen IBD severity in pregnant women?

04 Dec 2025

Sleep-related disorders up hypertension risk in postmenopausal women

02 Dec 2025

Postmenopausal women with sleep-related disorders face increased risk of hypertension, according to a US-based study.

Sleep-related disorders up hypertension risk in postmenopausal women

02 Dec 2025

Original New Drug Application Approvals by US FDA (16-31 October 2025)

02 Dec 2025

New drug applications approved by US FDA as of 16-31 October 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16-31 October 2025)

02 Dec 2025

Prepregnancy metformin use tied to lower risk of hyperemesis gravidarum

30 Nov 2025

Metformin treatment prior to conception is associated with a reduced risk for severe nausea and vomiting during pregnancy, according to new research.

Prepregnancy metformin use tied to lower risk of hyperemesis gravidarum

30 Nov 2025

Stopping GLP-1RAs before or shortly after conception ups pregnancy complications

28 Nov 2025

Discontinuing treatment with GLP-1RAs before or early into pregnancy in women with obesity may lead to more gestational weight gain and increased risk of preterm delivery, gestational diabetes, and hypertensive disorders of pregnancy, according to a retrospective study.

Stopping GLP-1RAs before or shortly after conception ups pregnancy complications

28 Nov 2025

Self-administered hypnosis alleviates hot flashes

23 Nov 2025

A self-administered hypnosis intervention helps reduce hot flashes and, in turn, improve the quality of life of postmenopausal women, as shown in a study.

Self-administered hypnosis alleviates hot flashes

23 Nov 2025

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Perimenopausal hormonal imbalances drive Alzheimer’s risk, plasma E2:P4 ratio a potential biomarker

Perimenopausal hormonal imbalances drive Alzheimer’s risk, plasma E2:P4 ratio a potential biomarker

Oral triterpenoid antifungal works against recurrent vulvovaginal candidiasis

Oral triterpenoid antifungal works against recurrent vulvovaginal candidiasis

Oral corticosteroids confer little to no GDM risk for expectant mothers

Oral corticosteroids confer little to no GDM risk for expectant mothers

In-utero exposure to INSTI-based ART regimens not a hazard to infant neurodevelopment

In-utero exposure to INSTI-based ART regimens not a hazard to infant neurodevelopment

Does aspirin use worsen IBD severity in pregnant women?

Does aspirin use worsen IBD severity in pregnant women?

Sleep-related disorders up hypertension risk in postmenopausal women

Sleep-related disorders up hypertension risk in postmenopausal women

Original New Drug Application Approvals by US FDA (16-31 October 2025)

Original New Drug Application Approvals by US FDA (16-31 October 2025)

Prepregnancy metformin use tied to lower risk of hyperemesis gravidarum

Prepregnancy metformin use tied to lower risk of hyperemesis gravidarum

Stopping GLP-1RAs before or shortly after conception ups pregnancy complications

Stopping GLP-1RAs before or shortly after conception ups pregnancy complications

Self-administered hypnosis alleviates hot flashes

Self-administered hypnosis alleviates hot flashes