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Intravenous PCA with hydromorphone outperforms oral morphine for severe cancer pain
In the management of severe cancer pain, intravenous patient-controlled analgesia (PCA) with hydromorphone delivers superior pain control with greater patient satisfaction as compared with conventional oral morphine, according to the phase III open-label SYLT-021 study.
Intravenous PCA with hydromorphone outperforms oral morphine for severe cancer pain
08 Oct 2024
Cemiplimab improves 5-year survival in advanced NSCLC
First-line cemiplimab monotherapy continues to provide durable overall (OS) and progression-free survival (PFS) benefits at 5 years compared with chemotherapy in advanced nonsmall cell lung cancer (NSCLC) patients with PD-L1 expression ≥50 percent, according to the results of the EMPOWER-Lung 1 study presented at WCLC 2024.
Cemiplimab improves 5-year survival in advanced NSCLC
08 Oct 2024
Osimertinib after CRT safe, effective in unresectable stage III EGFR-mutated NSCLC
Treatment with osimertinib following definitive chemoradiotherapy (CRT) demonstrates a manageable safety profile in patients with unresectable stage III EGFR-mutated nonsmall cell lung cancer (NSCLC), reports a study presented at WCLC 2024.
Osimertinib after CRT safe, effective in unresectable stage III EGFR-mutated NSCLC
07 Oct 2024
New model predicts HCC risk in noncirrhotic CHB patients
A novel prognostic model based on the viral loads of hepatitis B virus (HBV) demonstrates its utility in predicting and stratifying the risk of hepatocellular carcinoma (HCC) in noncirrhotic patients with chronic hepatitis B (CHB) who are not yet receiving antiviral therapy.
New model predicts HCC risk in noncirrhotic CHB patients
07 Oct 2024
Darolutamide + ADT, without docetaxel, shows efficacy benefits in mHSPC
Darolutamide plus androgen-deprivation therapy (ADT), without docetaxel, improves radiological progression-free survival (rPFS) and secondary efficacy outcomes vs placebo plus ADT in patients with metastatic hormone-sensitive prostate cancer (mHSPC), according to results of the global phase III ARANOTE trial presented at ESMO 2024.
Darolutamide + ADT, without docetaxel, shows efficacy benefits in mHSPC
07 Oct 2024
Aspirin may improve survival in PIK3CA-mutated colon cancer
Adjuvant treatment with aspirin appears to provide some protection in patients with resected, PIK3CA-mutant stage II and III colon cancer, demonstrating a clinically significant improvement (43 percent) in disease-free survival (DFS), suggests a study presented at ESMO Congress 2024.