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Mitapivat improves Hb levels in paediatric patients with PK deficiency

30 Dec 2025 by

Treatment with mitapivat increased haemoglobin (Hb) levels in children with pyruvate kinase (PK) deficiency who were not receiving regular blood transfusions, according to the ACTIVATE-Kids trial presented at ASH 2025.

Mitapivat improves Hb levels in paediatric patients with PK deficiency

30 Dec 2025

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

29 Dec 2025 by

In a subgroup analysis of patients with paroxysmal nocturnal haemoglobinuria (PNH) with a history of aplastic anaemia and concomitant immunosuppressive therapy (AA + IST), long-term treatment with iptacopan yields clinically meaningful improvements in haemoglobin levels, transfusion needs, and haemolysis control, with safety outcomes comparable to those in individuals without AA.

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

29 Dec 2025

What is the best intervention for fever-related discomfort in children?

28 Dec 2025 by

In children with fever-associated discomfort, pharmacological interventions appear safe and effective, while physical methods provide limited benefits, suggest the results of a systematic review.

What is the best intervention for fever-related discomfort in children?

28 Dec 2025

Interprofessional collaboration resolves drug-related problems in home care services in SG

24 Dec 2025 by

Collaborations among pharmacists, physicians, and nurses in home care results in significant improvements in identifying and resolving drug-related problems (DRPs), a Singapore study has shown.

Interprofessional collaboration resolves drug-related problems in home care services in SG

24 Dec 2025

Multidrug combos provide optimal glycaemic control in T2D patients

24 Dec 2025 by

A real-world study from India shows that multiple drug combinations effectively controlled blood sugar levels in individuals with type 2 diabetes (T2D).

Multidrug combos provide optimal glycaemic control in T2D patients

24 Dec 2025

Inhaled Technosphere insulin lowers HbA1c in Indian patients with T2D

24 Dec 2025 by

Inhaled Technosphere insulin significantly reduced HbA_1c levels in Indian individuals with type 2 diabetes (T2D) compared with placebo, according to a study presented at ATTD-ASIA 2025.

Inhaled Technosphere insulin lowers HbA1c in Indian patients with T2D

24 Dec 2025

Adjunctive lumateperone improves symptoms in major depressive disorder

23 Dec 2025

Lumateperone plus antidepressant therapy (ADT) demonstrates clinically meaningful improvements in depression symptoms and disease severity relative to placebo plus ADT, according to a study.

Adjunctive lumateperone improves symptoms in major depressive disorder

23 Dec 2025

Two DOACs show similar bleeding risks in head-to-head VTE trial

23 Dec 2025 by

In a post hoc analysis of the RENOVE trial, the direct oral anticoagulants (DOACs) rivaroxaban and apixaban demonstrate comparable risks of clinically relevant bleeding (CRB) and recurrent venous thromboembolism (VTE). These were observed across the crude, adjusted, and IPTW* analyses.

Two DOACs show similar bleeding risks in head-to-head VTE trial

23 Dec 2025

Domperidone for lactation support does not carry risk of new-onset psychosis

22 Dec 2025

Postpartum initiation of domperidone to support lactation does not appear to increase the risk of new-onset psychosis or emergency department (ED) visits or hospital admissions with mental health diagnoses, according to a retrospective study.

Domperidone for lactation support does not carry risk of new-onset psychosis

22 Dec 2025

Haemophilia B gene therapy benefit sustained through 5 years

22 Dec 2025 by

The final 5-year data from the phase III HOPE-B study demonstrated consistently low annualized bleeding rates and durable endogenous factor IX expression in haemophilia B patients, with no late hepatotoxicity or treatment-related oncogenicity observed.

Haemophilia B gene therapy benefit sustained through 5 years

22 Dec 2025

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Mitapivat improves Hb levels in paediatric patients with PK deficiency

Mitapivat improves Hb levels in paediatric patients with PK deficiency

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

What is the best intervention for fever-related discomfort in children?

What is the best intervention for fever-related discomfort in children?

Interprofessional collaboration resolves drug-related problems in home care services in SG

Interprofessional collaboration resolves drug-related problems in home care services in SG

Multidrug combos provide optimal glycaemic control in T2D patients

Multidrug combos provide optimal glycaemic control in T2D patients

Inhaled Technosphere insulin lowers HbA1c in Indian patients with T2D

Inhaled Technosphere insulin lowers HbA1c in Indian patients with T2D

Adjunctive lumateperone improves symptoms in major depressive disorder

Adjunctive lumateperone improves symptoms in major depressive disorder

Two DOACs show similar bleeding risks in head-to-head VTE trial

Two DOACs show similar bleeding risks in head-to-head VTE trial

Domperidone for lactation support does not carry risk of new-onset psychosis

Domperidone for lactation support does not carry risk of new-onset psychosis

Haemophilia B gene therapy benefit sustained through 5 years

Haemophilia B gene therapy benefit sustained through 5 years