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Orforglipron promotes weight loss across all menopausal stages

Once-daily treatment with the highest orforglipron dose is associated with significant reductions in body weight and waist circumference at week 72 in women with obesity or overweight, regardless of menopausal status, according to a post hoc analysis of the phase III ATTAIN-1 and -2 trials presented at ADA 2026.

Orforglipron promotes weight loss across all menopausal stages

7 hours ago

Baricitinib a promising steroid-sparing option in early polymyalgia rheumatica

19 hours ago by

The oral Janus kinase (JAK) inhibitor baricitinib has demonstrated efficacy in inducing and maintaining glucocorticoid-free remission in patients with early polymyalgia rheumatica, according to the phase 3 JAK-Spare trial.

Baricitinib a promising steroid-sparing option in early polymyalgia rheumatica

19 hours ago

Continuous vs bolus infusion of terlipressin: Which works best in acute variceal haemorrhage?

20 hours ago

Administration of terlipressin as either continuous or bolus infusion results in similar length of hospital stay, packed cell volume, rebleeding, and mortality rates in patients with acute variceal haemorrhage, a recent study has shown.

Continuous vs bolus infusion of terlipressin: Which works best in acute variceal haemorrhage?

20 hours ago

Buprenorphine extends antisuicide effect of ketamine in MDD

21 hours ago by

The use of buprenorphine helps prolong the antisuicidal benefits derived from treatment with ketamine in patients with major depressive disorder (MDD), suggests a study.

Buprenorphine extends antisuicide effect of ketamine in MDD

21 hours ago

SCB holds slight edge over PCB for PAD in SIRONA trial

23 hours ago by

The 3-year results from the SIRONA trial demonstrate the superiority of a sirolimus-coated balloon (SCB) over a paclitaxel-coated balloon (PCB) in terms of freedom from clinically driven target lesion revascularization (TLR) in patients with symptomatic femoropopliteal artery disease.

SCB holds slight edge over PCB for PAD in SIRONA trial

23 hours ago

Novel GLP-1 RA for weight management clears phase 2 study

a day ago

The investigational oral small-molecule glucagon-like peptide-1 receptor agonist (GLP-1 RA) elecoglipron yields meaningful weight reductions with a safety profile consistent with the drug class, according to a phase 2 dose-ranging study.

Novel GLP-1 RA for weight management clears phase 2 study

a day ago

PCV15 prevents AOM occurrence in children

a day ago by

The V114-032 trial, presented at ESPID 2026, finds that administering the 15-valent pneumococcal conjugate vaccine (PCV15) reduces the incidence of first vaccine-type acute otitis media (VT-AOM) among healthy children.

PCV15 prevents AOM occurrence in children

a day ago

Topical chlorhexidine 1% reduces maternal, neonatal bacterial colonization

a day ago

Topical application of chlorhexidine 1% proves effective at reducing bacterial load in both mothers and neonates, according to the results of a randomized controlled trial.

Topical chlorhexidine 1% reduces maternal, neonatal bacterial colonization

a day ago

Oral probiotic supplementation may lower risk of preterm delivery recurrence

a day ago by

Oral supplementation with probiotics containing Clostridium species may protect against the recurrence of spontaneous preterm delivery in high-risk pregnant women, according to a prospective, single-arm, trial conducted in Japan.

Oral probiotic supplementation may lower risk of preterm delivery recurrence

a day ago

Opioid systems influence ketamine’s antidepressant effect

a day ago

Complex interactions between glutamatergic, opioidergic, and GABAergic systems modulate the antidepressant effects of ketamine on cerebral blood flow (CBF) in patients with major depressive disorder (MDD), suggests a recent study.

Opioid systems influence ketamine’s antidepressant effect

a day ago

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Orforglipron promotes weight loss across all menopausal stages

Orforglipron promotes weight loss across all menopausal stages

Baricitinib a promising steroid-sparing option in early polymyalgia rheumatica

Baricitinib a promising steroid-sparing option in early polymyalgia rheumatica

Continuous vs bolus infusion of terlipressin: Which works best in acute variceal haemorrhage?

Continuous vs bolus infusion of terlipressin: Which works best in acute variceal haemorrhage?

Buprenorphine extends antisuicide effect of ketamine in MDD

Buprenorphine extends antisuicide effect of ketamine in MDD

SCB holds slight edge over PCB for PAD in SIRONA trial

SCB holds slight edge over PCB for PAD in SIRONA trial

Novel GLP-1 RA for weight management clears phase 2 study

Novel GLP-1 RA for weight management clears phase 2 study

PCV15 prevents AOM occurrence in children

PCV15 prevents AOM occurrence in children

Topical chlorhexidine 1% reduces maternal, neonatal bacterial colonization

Topical chlorhexidine 1% reduces maternal, neonatal bacterial colonization

Oral probiotic supplementation may lower risk of preterm delivery recurrence

Oral probiotic supplementation may lower risk of preterm delivery recurrence

Opioid systems influence ketamine’s antidepressant effect

Opioid systems influence ketamine’s antidepressant effect