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Too much or too little folate during pregnancy may raise heart risk in offspring

Too much or too little folate during pregnancy may raise heart risk in offspring

In early to mid-pregnancy, low or excessively high maternal serum folate levels carry a heightened risk of congenital heart disease (CHD) in the offspring, as shown in a study.

Too much or too little folate during pregnancy may raise heart risk in offspring

Original New Drug Application Approvals by US FDA (1-15 October 2024)

Original New Drug Application Approvals by US FDA (1-15 October 2024)

New drug applications approved by US FDA as of 1-15 October 2024 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (1-15 October 2024)

Induction chemo followed by chemoradiotherapy bumps up survival in advanced cervical cancer

Induction chemo followed by chemoradiotherapy bumps up survival in advanced cervical cancer

A short-course induction chemotherapy conducted prior to chemoradiotherapy appears to deliver significant survival boost in locally advanced cervical cancer, according to the phase III GCIG INTERLACE trial.

Induction chemo followed by chemoradiotherapy bumps up survival in advanced cervical cancer

21 Oct 2024

Sperm fragmentation a risk factor for pregnancy complications

Sperm fragmentation a risk factor for pregnancy complications

High sperm deoxyribonucleic acid fragmentation index (DFI) level appears to negatively affect the outcome of pregnancies achieved with assisted reproductive technology (ART), being linked to increased risks of complications such as preterm birth and pre-eclampsia in a new research.

Sperm fragmentation a risk factor for pregnancy complications

Fuzuloparib ± apatinib improves PFS in BRCA-mutated metastatic breast cancer

Fuzuloparib ± apatinib improves PFS in BRCA-mutated metastatic breast cancer

Treatment with fuzuloparib, with or without apatinib, significantly improved progression-free survival (PFS) in patients with HER2– metastatic breast cancer (mBC) harbouring germline BRCA1/2 (gBRCA1/2) mutations compared with standard chemotherapy, according to results of a phase III study presented at ESMO 2024.

Fuzuloparib ± apatinib improves PFS in BRCA-mutated metastatic breast cancer

Group intervention may prevent maternal obesity transmission

Group intervention may prevent maternal obesity transmission

A group prenatal care intervention appears beneficial in addressing several factors associated with intergenerational transmission of obesity, suggests a study in American Samoa.

Group intervention may prevent maternal obesity transmission

17 Oct 2024

Exercise may cut breast cancer risk

Exercise may cut breast cancer risk

A study conducted among Vietnamese women found that engaging in regular exercise leads to a reduction in the overall risk of breast cancer, especially the HER2-enriched subtype.

Exercise may cut breast cancer risk

16 Oct 2024

Aspirin during pregnancy may enhance cognitive function in children

Aspirin during pregnancy may enhance cognitive function in children

A prospective cohort study has linked prenatal use of aspirin to better neurocognitive development in offspring.

Aspirin during pregnancy may enhance cognitive function in children

KEYNOTE-522 final data boost pembrolizumab role in early breast cancer

KEYNOTE-522 final data boost pembrolizumab role in early breast cancer

Results from the phase III KEYNOTE-522 study presented at ESMO 2024 show a statistically significant and clinically meaningful improvement in overall survival (OS) with neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab compared with neoadjuvant chemo alone for previously untreated, high-risk, early-stage triple-negative breast cancer (TNBC).

KEYNOTE-522 final data boost pembrolizumab role in early breast cancer

09 Oct 2024

Women with hypertension face decreased fecundability

Women with hypertension face decreased fecundability

Hypertension, regardless of blood pressure control, appears to exert a negative influence on fecundability in women, as reported in a study.

Women with hypertension face decreased fecundability

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