News &amp; Updates

Knowledge and awareness of the gut microbiome are relatively low among the general population in Singapore, but practices of gut health modification are common, reports a study.

Gut microbiome awareness low, gut health practices high in SG

Favourable lifestyle helps prevent r-axSpA development

Individuals who adhere to a favourable lifestyle have a low risk of developing radiographic axial spondyloarthritis (r-axSpA), according to study.

Favourable lifestyle helps prevent r-axSpA development

Rifasutenizol tackles H. pylori infection

Rifasutenizol demonstrates efficacy in the treatment of Helicobacter pylori infection, according to the results of the phase III EVEREST-HP trial.

Rifasutenizol tackles H. pylori infection

Olezarsen lowers triglycerides in patients with moderate HTG, high CV risk

Treatment with olezarsen 50 or 80 mg significantly reduced triglyceride levels in patients with moderate hypertriglyceridaemia (HTG) and elevated cardiovascular (CV) risk compared with placebo, according to the Essence-TIMI 73b trial presented at ESC 2025.

Olezarsen lowers triglycerides in patients with moderate HTG, high CV risk

Should PPIs be avoided in mHSPC patients treated with upfront docetaxel?

A landmark analysis of data from a Hong Kong prostate cancer database found that use of proton-pump inhibitors (PPIs) was associated with inferior oncological outcomes in patients with de novo metastatic hormone-sensitive prostate cancer (mHSPC) who received upfront docetaxel.

Should PPIs be avoided in mHSPC patients treated with upfront docetaxel?

23 Sep 2025

Can gut microbiome composition predict response to pembrolizumab +/- chemo in treatment-naïve mNSCLC?

Research findings from Yonsei Cancer Center in South Korea, presented at European Society for Medical Oncology Targeted Anticancer Therapies Asia Congress (ESMO TAT Asia) 2025, suggest a correlation between butyrate-producing Faecalibacterium enrichment and clinical response to pembrolizumab with or without chemotherapy in treatment-naïve patients with metastatic non-small-cell lung cancer (mNSCLC).

Can gut microbiome composition predict response to pembrolizumab +/- chemo in treatment-naïve mNSCLC?

23 Sep 2025

Sleep regularity matters for mental health

22 Sep 2025 by

New research suggests that having a consistent sleep schedule may decrease the risks of depression and anxiety, regardless of the duration of sleep.

Sleep regularity matters for mental health

Noninvasive model predicts BP decrease post-RDN for arterial hypertension

The use of a noninvasive bivariate model can accurately predict blood pressure (BP) response at 6 and 12 months after renal denervation (RDN) in patients with resistant hypertension, a study has shown.

Noninvasive model predicts BP decrease post-RDN for arterial hypertension

Hypertensive disorders of pregnancy may impair childhood neurodevelopment

22 Sep 2025 by

Hypertensive disorders of pregnancy (HDPs) appear to increase the odds of adverse neurodevelopmental and cognitive outcomes, such as autism and attention-deficit/hyperactivity disorder (ADHD), in the offspring, suggest the results of a meta-analysis.

Hypertensive disorders of pregnancy may impair childhood neurodevelopment

22 Sep 2025

Mediterranean–DASH diet improves health outcomes in T2D, hypertension

Adherence to the Mediterranean–Dietary Approaches to Stop Hypertension (DASH) diet leads to improvements in anthropometric, laboratory parameters, and blood pressure (BP) in patients with type 2 diabetes (T2D) and hypertension, reports a study. This intervention also improves satiety levels throughout the day.

Mediterranean–DASH diet improves health outcomes in T2D, hypertension