News &amp; Updates

Being underweight puts adolescents at risk of osteoporosis in adulthood, and this risk further increases in those who remain underweight in their adult life, according to a retrospective study.

Underweight linked to increased osteoporosis risk

Switching to dual ART noninferior to continuing triple ART in maintaining viral suppression among PLWH

12 Aug 2025 by

Switching to maintenance dual antiretroviral therapy (ART) with DTG+3TC* or ATV/r+3TC** was noninferior to continuing triple current ART with TDF+3TC+EFV*** or DTG+3TC+TDF⁺ in maintaining virologic suppression for up to 96 weeks among people living with HIV (PLWH), according to the MODERATO trial presented at IAS 2025.

Switching to dual ART noninferior to continuing triple ART in maintaining viral suppression among PLWH

Diet linked to cognitive function in older adults via gut microbiota

12 Aug 2025 by

Greater adherence to dietary patterns that are beneficial to gut microbiota is associated with better cognitive function in older adults, according to data from the US National Health and Nutrition Examination Survey (NHANES). When these findings were validated in an independent Hong Kong osteoporosis cohort, higher dietary fibre intake significantly correlated with higher cognitive scores in older adults in Hong Kong.

Diet linked to cognitive function in older adults via gut microbiota

Periconceptional GLP-1RA exposure safety varies on indication for use

Exposure to glucagon-like peptide 1 receptor agonists (GLP-1RAs) during pregnancy poses a modest increase in the risk of preterm birth in the context of diabetes treatment, but there is no evidence of increased obstetric complications when the drugs are exclusively used for weight management, according to new research.

Periconceptional GLP-1RA exposure safety varies on indication for use

MASLD severity tied to poor cognitive function, HRQoL in patients with obesity

Greater severity in metabolic dysfunction-associated steatotic liver disease (MASLD) may impair cognitive function and health-related quality of life (HRQoL) in patients with overweight or obesity, suggests a study.

MASLD severity tied to poor cognitive function, HRQoL in patients with obesity

HBV vaccination, HIV PEP compliance low among young sexual assault victims

Many paediatric sexual assault victims do not receive hepatitis B virus (HBV) postexposure vaccination and have low compliance to HIV postexposure prophylaxis (PEP), reveals a study in Singapore.

HBV vaccination, HIV PEP compliance low among young sexual assault victims

11 Aug 2025

Adiposity levels may predict CRC risk

High adiposity levels are associated with the risk of colorectal cancer (CRC), suggest the results of a systematic review. However, standardization is necessary to improve understanding of the link between CRC and adiposity to enable comparisons across papers.

Adiposity levels may predict CRC risk

Lenacapavir serves its PURPOSE in young individuals

Twice-yearly subcutaneous (SC) lenacapavir demonstrates high efficacy, favourable safety, and consistent pharmacokinetics (PK) as pre-exposure prophylaxis (PrEP) for HIV-negative youth (aged 16–25 years) in an analysis of the phase III PURPOSE 1 (P1) and PURPOSE 2 (P2) trials.

Lenacapavir serves its PURPOSE in young individuals

11 Aug 2025

Vitamin D implicated in systemic lupus erythematosus

Patients with systemic lupus erythematosus (SLE) with low levels of vitamin D tend to have a more severe form of the disease, according to a systematic review and meta-analysis.

Vitamin D implicated in systemic lupus erythematosus

ADHD is a neurodevelopmental disorder that begins in early childhood and influences brain development