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No benefit to adding adjuvant chemo to hormonotherapy in high-risk breast cancer

29 Aug 2025

Adding adjuvant chemotherapy to hormonotherapy does not appear to improve survival outcomes in older women with high-risk estrogen receptor (ER)-positive, HER2-negative breast cancer and is even associated with more adverse events, as shown in a phase III study.

No benefit to adding adjuvant chemo to hormonotherapy in high-risk breast cancer

29 Aug 2025

Daridorexant benefits women with insomnia during menopausal transition

29 Aug 2025 by

Treatment with daridorexant improved sleep outcomes and daytime functioning in women with insomnia disorder during the menopausal transition, according to a study presented at EAN 2025.

Daridorexant benefits women with insomnia during menopausal transition

29 Aug 2025

7,000 steps a day may be enough

29 Aug 2025 by

Walking 7,000 steps a day can offer the same health benefits as walking 10,000 steps a day, according to a comprehensive review and meta-analysis. Experts said it could be a more realistic target than the 10,000 steps, which is traditionally seen as the benchmark to reach.

7,000 steps a day may be enough

29 Aug 2025

Steroidal mineralocorticoid receptor antagonist offers no CV mortality benefit in dialysis patients

28 Aug 2025

Treatment with steroidal mineralocorticoid receptor antagonists does not appear to provide significant protection against cardiovascular mortality in patients undergoing dialysis, as shown in a systematic review and meta-analysis.

Steroidal mineralocorticoid receptor antagonist offers no CV mortality benefit in dialysis patients

28 Aug 2025

Mild behavioural impairment a warning signal for neurodegeneration

28 Aug 2025 by

People who report symptoms of mild behavioural impairment exhibit pronounced cortical thinning in regions involved in emotion regulation, belief formation, and cognitive control in the right side of the brain, according to a study.

Mild behavioural impairment a warning signal for neurodegeneration

28 Aug 2025

Rituximab not superior to conventional therapy in EGPA

28 Aug 2025

The use of rituximab falls short of demonstrating superiority over a conventional remission induction strategy in patients diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA), reveals a study.

Rituximab not superior to conventional therapy in EGPA

28 Aug 2025

Does hyperaldosteronism drive increased salt-sensitive BP in women?

28 Aug 2025 by

Salt-sensitive blood pressure (SSBP), aldosterone response to angiotensin II, and aldosterone/plasma renin activity (PRA) ratios are all greater in women than in men, suggests a study. However, men show higher levels of basal aldosterone and its secretagogues.

Does hyperaldosteronism drive increased salt-sensitive BP in women?

28 Aug 2025

Exercise plus diet reduces weight, but does little to improve hip pain

28 Aug 2025

The addition of a weight-loss diet to exercise does not appear to change hip pain severity, in adults with hip osteoarthritis and overweight or obesity. However, it results in improvements in most other outcomes such as body weight and body composition.

Exercise plus diet reduces weight, but does little to improve hip pain

28 Aug 2025

Should O2 exposure be reduced in critically ill patients on MV, O2?

28 Aug 2025 by

Findings from the UK-ROX* trial do not support reducing oxygen (O2) exposure by targeting a peripheral O2 saturation (SpO2) of 90 percent in adult patients receiving mechanical ventilation (MV) and supplemental O2 in the intensive care unit (ICU).

Should O2 exposure be reduced in critically ill patients on MV, O2?

28 Aug 2025

Adequate sleep, exercise reduce mortality in individuals with depression

28 Aug 2025

Getting enough sleep, engaging in high levels of physical activity, and cutting sedentary time appear to lower the risk of mortality in people with depression, according to a study.

Adequate sleep, exercise reduce mortality in individuals with depression

28 Aug 2025

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No benefit to adding adjuvant chemo to hormonotherapy in high-risk breast cancer

No benefit to adding adjuvant chemo to hormonotherapy in high-risk breast cancer

Daridorexant benefits women with insomnia during menopausal transition

Daridorexant benefits women with insomnia during menopausal transition

7,000 steps a day may be enough

7,000 steps a day may be enough

Steroidal mineralocorticoid receptor antagonist offers no CV mortality benefit in dialysis patients

Steroidal mineralocorticoid receptor antagonist offers no CV mortality benefit in dialysis patients

Mild behavioural impairment a warning signal for neurodegeneration

Mild behavioural impairment a warning signal for neurodegeneration

Rituximab not superior to conventional therapy in EGPA

Rituximab not superior to conventional therapy in EGPA

Does hyperaldosteronism drive increased salt-sensitive BP in women?

Does hyperaldosteronism drive increased salt-sensitive BP in women?

Exercise plus diet reduces weight, but does little to improve hip pain

Exercise plus diet reduces weight, but does little to improve hip pain

Should O2 exposure be reduced in critically ill patients on MV, O2?

Should O2 exposure be reduced in critically ill patients on MV, O2?

Adequate sleep, exercise reduce mortality in individuals with depression

Adequate sleep, exercise reduce mortality in individuals with depression