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Mitapivat improves Hb levels in paediatric patients with PK deficiency

30 Dec 2025 by

Treatment with mitapivat increased haemoglobin (Hb) levels in children with pyruvate kinase (PK) deficiency who were not receiving regular blood transfusions, according to the ACTIVATE-Kids trial presented at ASH 2025.

Mitapivat improves Hb levels in paediatric patients with PK deficiency

30 Dec 2025

Bladder preservation possible in select MIBC patients

29 Dec 2025 by

Neoadjuvant chemotherapy (NAC) with transurethral resection (TUR) for bladder preservation is feasible for some patients with muscle-invasive bladder cancer (MIBC) who meet established selection criteria, suggests a study. However, recurrence may occur beyond 10 years, warranting lifetime surveillance.

Bladder preservation possible in select MIBC patients

29 Dec 2025

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

29 Dec 2025 by

In a subgroup analysis of patients with paroxysmal nocturnal haemoglobinuria (PNH) with a history of aplastic anaemia and concomitant immunosuppressive therapy (AA + IST), long-term treatment with iptacopan yields clinically meaningful improvements in haemoglobin levels, transfusion needs, and haemolysis control, with safety outcomes comparable to those in individuals without AA.

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

29 Dec 2025

What is the best intervention for fever-related discomfort in children?

28 Dec 2025 by

In children with fever-associated discomfort, pharmacological interventions appear safe and effective, while physical methods provide limited benefits, suggest the results of a systematic review.

What is the best intervention for fever-related discomfort in children?

28 Dec 2025

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

27 Dec 2025

Peroral endoscopic myotomy (POEM) is safe and feasible in older adults with achalasia despite their comorbidities, suggests a study.

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

27 Dec 2025

Rope skipping: Is high better than moderate intensity for cardiorespiratory fitness?

26 Dec 2025

High-intensity interval (HIIE) and moderate-intensity continuous exercises (MICE) using rope skipping are both effective in improving cardiorespiratory fitness (CRF) in young adults, according to a study. Moreover, both strategies are similarly enjoyable.

Rope skipping: Is high better than moderate intensity for cardiorespiratory fitness?

26 Dec 2025

Pharmacogenomics combines pharmacology and genomics to better understand how genetic differences influence individual responses to medications.

26 Dec 2025 by

Genetic makeup may be the reason why some medicines function for some people but not others.

Pharmacogenomics combines pharmacology and genomics to better understand how genetic differences influence individual responses to medications.

26 Dec 2025

Prior CD-related abdominal surgery has no bearing on pregnancy outcomes

25 Dec 2025 by

In expectant mothers, a history of abdominal surgery for Crohn’s disease (CD) exerts no adverse effect on pregnancy, neonatal, or wound healing outcomes, according to the prospective PIANO study.

Prior CD-related abdominal surgery has no bearing on pregnancy outcomes

25 Dec 2025

Loose stools worsen life quality in women with faecal incontinence

25 Dec 2025

In women with faecal incontinence (FI), faecal consistency of Bristol Stool Chart (BSC) ≥5 results in significantly worse clinical severity and quality of life (QoL), reports a study.

Loose stools worsen life quality in women with faecal incontinence

25 Dec 2025

Routine coffee drinking may have BP-lowering effect

25 Dec 2025

Regular coffee consumption appears to be associated with decreases in blood pressure (BP) levels, as according to a Mendelian randomization analysis.

Routine coffee drinking may have BP-lowering effect

25 Dec 2025

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Mitapivat improves Hb levels in paediatric patients with PK deficiency

Mitapivat improves Hb levels in paediatric patients with PK deficiency

Bladder preservation possible in select MIBC patients

Bladder preservation possible in select MIBC patients

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

What is the best intervention for fever-related discomfort in children?

What is the best intervention for fever-related discomfort in children?

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

Rope skipping: Is high better than moderate intensity for cardiorespiratory fitness?

Rope skipping: Is high better than moderate intensity for cardiorespiratory fitness?

Pharmacogenomics combines pharmacology and genomics to better understand how genetic differences influence individual responses to medications.

Pharmacogenomics combines pharmacology and genomics to better understand how genetic differences influence individual responses to medications.

Prior CD-related abdominal surgery has no bearing on pregnancy outcomes

Prior CD-related abdominal surgery has no bearing on pregnancy outcomes

Loose stools worsen life quality in women with faecal incontinence

Loose stools worsen life quality in women with faecal incontinence

Routine coffee drinking may have BP-lowering effect

Routine coffee drinking may have BP-lowering effect