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Personalizing upfront treatment options for advanced EGFRm NSCLC

26 May 2025 by

This article will summarize the latest developments in the first-line management of advanced EGFRm NSCLC and highlight key consideration factors.

Personalizing upfront treatment options for advanced EGFRm NSCLC

26 May 2025

No APHINITY between statin use and survival outcomes in early HER2-positive breast cancer

26 May 2025 by

Statin use was not associated with improved survival outcomes in the phase III APHINITY trial investigating the addition of pertuzumab to trastuzumab and chemotherapy as adjuvant treatment for patients with early HER2-positive breast cancer (BC).

No APHINITY between statin use and survival outcomes in early HER2-positive breast cancer

26 May 2025

Next-generation KRASG12C inhibitor monotherapy convenient, shows promising antitumour activity

25 May 2025 by

A multinational phase I study led by the Chinese University of Hong Kong (CUHK) reports an overall objective response rate (ORR) of >70 percent in advanced solid KRAS^G12C-mutant tumours treated with D3S-001, a next-generation KRAS^G12C inhibitor developed in mainland China.

Next-generation KRASG12C inhibitor monotherapy convenient, shows promising antitumour activity

25 May 2025

GLP-1RAs help reduce risk of gastrointestinal cancers

23 May 2025 by

Treatment with glucagon-like peptide-1 receptor agonists (GLP-1RAs), as opposed to insulin or metformin, provides a protective benefit against the development of gastrointestinal cancers, as shown in a study presented at DDW 2025.

GLP-1RAs help reduce risk of gastrointestinal cancers

23 May 2025

Dostarlimab may eliminate the need for surgery in early-stage dMMR tumours

23 May 2025 by

PD-1 blockade with dostarlimab may eliminate the need for surgery in patients with early-stage mismatch repair–deficient (dMMR) solid tumours amenable to curative intent surgery, a phase II trial has shown.

Dostarlimab may eliminate the need for surgery in early-stage dMMR tumours

23 May 2025

Ageing-related diseases occur early among childhood cancer survivors

23 May 2025

Survivors of childhood cancer undergo accelerated ageing, with a recent study showing a 2-decade earlier onset and a greater lifetime risk of common and life-threatening chronic health conditions (CHCs).

Ageing-related diseases occur early among childhood cancer survivors

23 May 2025

Watch-and-wait approach feasible for therapy-responsive rectal cancer

19 May 2025

Survival outcomes do not differ between patients with locally advanced rectal cancer treated with mandatory total mesorectal excision (TME) and those on selective watch-and-wait (WW) strategies following total neoadjuvant therapy (TNT), reports a study.

Watch-and-wait approach feasible for therapy-responsive rectal cancer

19 May 2025

Neoadjuvant therapy extends survival in left-sided resectable pancreatic cancer

17 May 2025

Patients with left-sided resectable pancreatic cancer (RPC) enjoy improved overall survival (OS) with neoadjuvant therapy compared with upfront surgery, a recent study has shown.

Neoadjuvant therapy extends survival in left-sided resectable pancreatic cancer

17 May 2025

CAR T-cell therapy improves survival in non-Hodgkin lymphoma

15 May 2025

Treatment with chimeric antigen receptor T-cell therapies (CAR-TCT) results in significant improvements in overall (OS) and progression-free survival (PFS) among patients with refractory non-Hodgkin lymphoma (NHL) but shows no substantial effect on event-free survival (EFS), reports a study.

CAR T-cell therapy improves survival in non-Hodgkin lymphoma

15 May 2025

First-line tislelizumab plus chemo shows benefit in nsq-NSCLC with high PD-L1 expression

15 May 2025 by

First-line treatment with tislelizumab plus chemotherapy showed better survival outcomes and response among patients with locally advanced or metastatic non-squamous non-small cell lung cancer (nsq-NSCLC), particularly those with high PD-L1 expression, compared with chemotherapy alone, according to a subgroup analysis of the phase III RATIONALE-304 trial presented at ELCC 2025.

First-line tislelizumab plus chemo shows benefit in nsq-NSCLC with high PD-L1 expression

15 May 2025

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Personalizing upfront treatment options for advanced EGFRm NSCLC

Personalizing upfront treatment options for advanced EGFRm NSCLC

No APHINITY between statin use and survival outcomes in early HER2-positive breast cancer

No APHINITY between statin use and survival outcomes in early HER2-positive breast cancer

Next-generation KRASG12C inhibitor monotherapy convenient, shows promising antitumour activity

Next-generation KRASG12C inhibitor monotherapy convenient, shows promising antitumour activity

GLP-1RAs help reduce risk of gastrointestinal cancers

GLP-1RAs help reduce risk of gastrointestinal cancers

Dostarlimab may eliminate the need for surgery in early-stage dMMR tumours

Dostarlimab may eliminate the need for surgery in early-stage dMMR tumours

Ageing-related diseases occur early among childhood cancer survivors

Ageing-related diseases occur early among childhood cancer survivors

Watch-and-wait approach feasible for therapy-responsive rectal cancer

Watch-and-wait approach feasible for therapy-responsive rectal cancer

Neoadjuvant therapy extends survival in left-sided resectable pancreatic cancer

Neoadjuvant therapy extends survival in left-sided resectable pancreatic cancer

CAR T-cell therapy improves survival in non-Hodgkin lymphoma

CAR T-cell therapy improves survival in non-Hodgkin lymphoma

First-line tislelizumab plus chemo shows benefit in nsq-NSCLC with high PD-L1 expression

First-line tislelizumab plus chemo shows benefit in nsq-NSCLC with high PD-L1 expression