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Aficamten retains upper hand over metoprolol for oHCM in subanalysis

14 Sep 2026 by

Results from a subanalysis of the MAPLE-HCM* trial presented at ESC 2026 continue to support the superiority of aficamten over metoprolol in patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) irrespective of beta-blocker (BB) use at screening and prior standard-of-care (SoC) status.

Aficamten retains upper hand over metoprolol for oHCM in subanalysis

14 Sep 2026

Vibrator use beneficial in women with sexual dysfunction, pelvic floor disorders

14 Sep 2026

An intervention that incorporates scheduled vibrator use with an educational handout helps improve outcomes in women with sexual dysfunction and pelvic floor disorders, as shown in a randomized controlled trial.

Vibrator use beneficial in women with sexual dysfunction, pelvic floor disorders

14 Sep 2026

Real-world data support broader use of durvalumab + chemo in advanced BTC

14 Sep 2026 by

Real-world data from patients with advanced biliary tract cancer (BTC) treated with first-line durvalumab plus cisplatin and gemcitabine across 12 countries/regions show similar survival outcomes between those who would not be eligible for the TOPAZ-1 trial and results reported in the durvalumab arm of TOPAZ-1, with no evident increase in toxicity.

Real-world data support broader use of durvalumab + chemo in advanced BTC

14 Sep 2026

Greater adherence to MIND diet improves global cognition

13 Sep 2026

Higher adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet scores from baseline significantly enhances global cognitive function in community-dwelling adults, a study has shown.

Greater adherence to MIND diet improves global cognition

13 Sep 2026

Vaginal oestrogen improves prolapse surgery outcomes

13 Sep 2026

In postmenopausal women undergoing primary prolapse surgery, perioperative treatment with vaginal oestrogen is associated with improvements in patient-reported outcomes and pelvic floor-related quality of life, as shown in a multicentre study.

Vaginal oestrogen improves prolapse surgery outcomes

13 Sep 2026

Novel oral relaxin receptor agonist shows promise in chronic heart failure

12 Sep 2026 by

In patients with chronic heart failure (HF), the addition of the oral relaxin family peptide receptor 1 (RXFP1) agonist AZD5462 to guideline-directed medical therapies (GDMTs) may help improve cardiac remodelling and haemodynamics across a wide range of left ventricular ejection fraction (LVEF), according to the phase IIb LUMINARA study.

Novel oral relaxin receptor agonist shows promise in chronic heart failure

12 Sep 2026

Elevated serum ApoE ups incident CVD risk

12 Sep 2026 by

Higher circulating apolipoprotein A (ApoE) concentrations appear to increase the risk for incidence major adverse cardiovascular events (MACE), ischaemic heart disease (IHD), and heart failure, suggests a study.

Elevated serum ApoE ups incident CVD risk

12 Sep 2026

Perinatal depression carries increased risk of infant death

12 Sep 2026

Infants born to mothers with depressive symptoms have a higher risk of death within the first year of life compared with those born to mothers without depressive symptoms, according to a retrospective study.

Perinatal depression carries increased risk of infant death

12 Sep 2026

GLP-1RAs may help with binge eating

11 Sep 2026 by

In individuals with overweight or obesity, treatment with a glucagon-like peptide-1 receptor agonist (GLP-1RA) appears to reduce binge eating severity and associated behaviours, including loss of control eating and disinhibited eating, according to a meta-analysis.

GLP-1RAs may help with binge eating

11 Sep 2026

Cumulative BP exposure a better predictor of CV outcomes, mortality

11 Sep 2026

Cumulative blood pressure (BP) exposure over the previous 10 years results in improved prediction of incident cardiovascular events and mortality beyond that derived from a single value, according to a study.

Cumulative BP exposure a better predictor of CV outcomes, mortality

11 Sep 2026

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Aficamten retains upper hand over metoprolol for oHCM in subanalysis

Aficamten retains upper hand over metoprolol for oHCM in subanalysis

Vibrator use beneficial in women with sexual dysfunction, pelvic floor disorders

Vibrator use beneficial in women with sexual dysfunction, pelvic floor disorders

Real-world data support broader use of durvalumab + chemo in advanced BTC

Real-world data support broader use of durvalumab + chemo in advanced BTC

Greater adherence to MIND diet improves global cognition

Greater adherence to MIND diet improves global cognition

Vaginal oestrogen improves prolapse surgery outcomes

Vaginal oestrogen improves prolapse surgery outcomes

Novel oral relaxin receptor agonist shows promise in chronic heart failure

Novel oral relaxin receptor agonist shows promise in chronic heart failure

Elevated serum ApoE ups incident CVD risk

Elevated serum ApoE ups incident CVD risk

Perinatal depression carries increased risk of infant death

Perinatal depression carries increased risk of infant death

GLP-1RAs may help with binge eating

GLP-1RAs may help with binge eating

Cumulative BP exposure a better predictor of CV outcomes, mortality

Cumulative BP exposure a better predictor of CV outcomes, mortality