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Tirzepatide reduces weight in women with obesity across reproductive stages
Treatment with tirzepatide, compared with placebo, results in significant reductions in body weight, waist circumference, and waist-to-height ratio (WHtR) among women with obesity or overweight and without type 2 diabetes (T2D), regardless of reproductive stage.
Tirzepatide reduces weight in women with obesity across reproductive stages
09 May 2025
BRCA-negative ovarian cancer gets PFS gains with pembrolizumab plus olaparib
First-line treatment with chemotherapy plus pembrolizumab followed by maintenance with pembrolizumab plus olaparib, with or without bevacizumab, appears to prolong progression-free survival (PFS) in advanced epithelial ovarian cancer without BRCA 1/2 mutations, according to data from the phase III ENGOT-ov43/GOG-3036/KEYLYNK-001 trial.
BRCA-negative ovarian cancer gets PFS gains with pembrolizumab plus olaparib
08 May 2025
Monoclonal antibodies vs COVID-19 up risks of hepatotoxicity, neutropenia
Treatment with monoclonal antibodies (mAbs) among COVID-19 patients is associated with a higher risk of hepatotoxicity and neutropenia when compared with standard of care (SoC) or placebo, reports a study.
Monoclonal antibodies vs COVID-19 up risks of hepatotoxicity, neutropenia
08 May 2025
KRAS-mutant advanced NSCLC responds to fulzerasib–cetuximab combo
First-line treatment with the combination of fulzerasib and cetuximab appears to induce deep and durable responses in patients with advanced nonsmall cell lung cancer (NSCLC) harbouring KRAS G12C mutation, in addition to having a favourable safety profile, according to the results of the phase II, open-label, single-arm KROCUS trial.
KRAS-mutant advanced NSCLC responds to fulzerasib–cetuximab combo
07 May 2025
Add-on bireociclib promising for HR+/HER2- ABC following ET failure
In the interim analysis of the phase III BRIGHT-2 study, adding the CDK4/6 inhibitor bireociclib to fulvestrant prolongs progression-free survival (PFS) in Chinese women with HR+/HER2- advanced breast cancer (ABC) who progressed on or after endocrine therapy (ET).