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Multikingdom microbial biomarker test for autism risk assessment aids earlier diagnosis & intervention

30 Dec 2025 by

Researchers from the Chinese University of Hong Kong (CUHK) have developed the world’s first artificial intelligence (AI)–powered multikingdom microbial biomarker test for autism spectrum disorder (ASD) risk assessment. By accurately excluding ASD in low-risk cases, the test may facilitate earlier diagnosis and intervention in high-risk groups.

Multikingdom microbial biomarker test for autism risk assessment aids earlier diagnosis & intervention

30 Dec 2025

Mitapivat improves Hb levels in paediatric patients with PK deficiency

30 Dec 2025 by

Treatment with mitapivat increased haemoglobin (Hb) levels in children with pyruvate kinase (PK) deficiency who were not receiving regular blood transfusions, according to the ACTIVATE-Kids trial presented at ASH 2025.

Mitapivat improves Hb levels in paediatric patients with PK deficiency

30 Dec 2025

Bladder preservation possible in select MIBC patients

29 Dec 2025 by

Neoadjuvant chemotherapy (NAC) with transurethral resection (TUR) for bladder preservation is feasible for some patients with muscle-invasive bladder cancer (MIBC) who meet established selection criteria, suggests a study. However, recurrence may occur beyond 10 years, warranting lifetime surveillance.

Bladder preservation possible in select MIBC patients

29 Dec 2025

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

29 Dec 2025 by

In a subgroup analysis of patients with paroxysmal nocturnal haemoglobinuria (PNH) with a history of aplastic anaemia and concomitant immunosuppressive therapy (AA + IST), long-term treatment with iptacopan yields clinically meaningful improvements in haemoglobin levels, transfusion needs, and haemolysis control, with safety outcomes comparable to those in individuals without AA.

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

29 Dec 2025

What is the best intervention for fever-related discomfort in children?

28 Dec 2025 by

In children with fever-associated discomfort, pharmacological interventions appear safe and effective, while physical methods provide limited benefits, suggest the results of a systematic review.

What is the best intervention for fever-related discomfort in children?

28 Dec 2025

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

27 Dec 2025

Peroral endoscopic myotomy (POEM) is safe and feasible in older adults with achalasia despite their comorbidities, suggests a study.

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

27 Dec 2025

Rope skipping: Is high better than moderate intensity for cardiorespiratory fitness?

26 Dec 2025

High-intensity interval (HIIE) and moderate-intensity continuous exercises (MICE) using rope skipping are both effective in improving cardiorespiratory fitness (CRF) in young adults, according to a study. Moreover, both strategies are similarly enjoyable.

Rope skipping: Is high better than moderate intensity for cardiorespiratory fitness?

26 Dec 2025

Spironolactone: A longtime ally in the fight against heart failure, hypertension, edema, and primary aldosteronism

26 Dec 2025

Spironolactone as a diuretic has a wide array of both diagnostic and therapeutic uses — from treatment of non-cardiac edema to its established use in cardiovascular disease. In high doses, spironolactone is indicated to treat edema secondary to hepatic cirrhosis, nephrotic syndrome and heart failure with reduced ejection fraction (HFrEF).

Spironolactone: A longtime ally in the fight against heart failure, hypertension, edema, and primary aldosteronism

26 Dec 2025

A new course for cardiovascular outcomes in ACS

26 Dec 2025

Cardiovascular diseases continue to be a leading cause of death globally, with an estimated 17.9 million deaths annually due to these conditions. In the Philippines, the situation is no different. Statistics covering January to April of 2025 show that ischemic heart diseases were the leading cause of death in the country, accounting for 20% of all deaths during this period.

A new course for cardiovascular outcomes in ACS

26 Dec 2025

Takes two to “tango”: Synergistic efficacy and safety of the losartan–amlodipine pill

26 Dec 2025

Losartan potassium combined with amlodipine besilate has quietly become one of the more dependable combinations in hypertension management, the kind of duo that works so well together that one almost takes for granted how much clinical frustration it saves one

Takes two to “tango”: Synergistic efficacy and safety of the losartan–amlodipine pill

26 Dec 2025

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Multikingdom microbial biomarker test for autism risk assessment aids earlier diagnosis & intervention

Multikingdom microbial biomarker test for autism risk assessment aids earlier diagnosis & intervention

Mitapivat improves Hb levels in paediatric patients with PK deficiency

Mitapivat improves Hb levels in paediatric patients with PK deficiency

Bladder preservation possible in select MIBC patients

Bladder preservation possible in select MIBC patients

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

What is the best intervention for fever-related discomfort in children?

What is the best intervention for fever-related discomfort in children?

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

Rope skipping: Is high better than moderate intensity for cardiorespiratory fitness?

Rope skipping: Is high better than moderate intensity for cardiorespiratory fitness?

Spironolactone: A longtime ally in the fight against heart failure, hypertension, edema, and primary aldosteronism

Spironolactone: A longtime ally in the fight against heart failure, hypertension, edema, and primary aldosteronism

A new course for cardiovascular outcomes in ACS

A new course for cardiovascular outcomes in ACS

Takes two to “tango”: Synergistic efficacy and safety of the losartan–amlodipine pill

Takes two to “tango”: Synergistic efficacy and safety of the losartan–amlodipine pill