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Obefazimod hits targets in identical trials on active UC

31 Dec 2025 by

Two phase III induction trials have demonstrated the efficacy and safety of obefazimod, an oral, first-in-class, small molecule, for the treatment of adults with moderate-to-severe ulcerative colitis (UC).

Obefazimod hits targets in identical trials on active UC

31 Dec 2025

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

27 Dec 2025

Peroral endoscopic myotomy (POEM) is safe and feasible in older adults with achalasia despite their comorbidities, suggests a study.

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

27 Dec 2025

Prior CD-related abdominal surgery has no bearing on pregnancy outcomes

25 Dec 2025 by

In expectant mothers, a history of abdominal surgery for Crohn’s disease (CD) exerts no adverse effect on pregnancy, neonatal, or wound healing outcomes, according to the prospective PIANO study.

Prior CD-related abdominal surgery has no bearing on pregnancy outcomes

25 Dec 2025

Loose stools worsen life quality in women with faecal incontinence

25 Dec 2025

In women with faecal incontinence (FI), faecal consistency of Bristol Stool Chart (BSC) ≥5 results in significantly worse clinical severity and quality of life (QoL), reports a study.

Loose stools worsen life quality in women with faecal incontinence

25 Dec 2025

Oncological outcomes in pancreatic cancer similar with less-invasive vs open surgery

18 Dec 2025

In patients with upfront resectable pancreatic cancer, minimally invasive left pancreatectomy (MILP) and open left pancreatectomy (OLP) appear to result in similar oncological outcomes, as shown in the DIPLOMA trial.

Oncological outcomes in pancreatic cancer similar with less-invasive vs open surgery

18 Dec 2025

Lactulose, Tai chi prevent falls in patients with cirrhosis, portal hypertension

18 Dec 2025 by

The LIVE-SMART trial presented at AASLD 2025 shows that lactulose and Tai chi may prevent falls in individuals with cirrhosis and portal hypertension.

Lactulose, Tai chi prevent falls in patients with cirrhosis, portal hypertension

18 Dec 2025

Inebilizumab MITIGATEs flares in IgG4-RD with pancreatic, hepatobiliary involvement

15 Dec 2025 by

The post hoc subgroup analysis of the phase III MITIGATE trial shows the benefit of the humanized monoclonal anti-CD19 antibody inebilizumab in adults with IgG4-related disease (IgG4-RD) with pancreas, bile duct, and liver involvement at baseline.

Inebilizumab MITIGATEs flares in IgG4-RD with pancreatic, hepatobiliary involvement

15 Dec 2025

Cilofexor does not halt fibrosis progression in noncirrhotic PSC

13 Dec 2025

Treatment with cilofexor in patients with noncirrhotic primary sclerosing cholangitis (PSC) does not appear to reduce the rate of fibrosis progression, according to a phase III study.

Cilofexor does not halt fibrosis progression in noncirrhotic PSC

13 Dec 2025

Vedolizumab better used in early- vs late-stage Crohn’s disease

13 Dec 2025

In patients with Crohn’s disease (CD), initiating treatment with vedolizumab early than late in the disease course may lead to better safety and efficacy outcomes, according to a phase IV open-label cohort study.

Vedolizumab better used in early- vs late-stage Crohn’s disease

13 Dec 2025

Does palmitoleic acid supplementation reduce hs-CRP in adults?

10 Dec 2025

Supplementation with palmitoleic acid (POA) 500 or 1,000 mg/day does not appear to substantially reduce high-sensitivity C-reactive protein (hs-CRP) or change other biomarkers in adults relative to placebo, reports a study.

Does palmitoleic acid supplementation reduce hs-CRP in adults?

10 Dec 2025

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Obefazimod hits targets in identical trials on active UC

Obefazimod hits targets in identical trials on active UC

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

Peroral endoscopic myotomy for achalasia feasible in older adults with comorbidities

Prior CD-related abdominal surgery has no bearing on pregnancy outcomes

Prior CD-related abdominal surgery has no bearing on pregnancy outcomes

Loose stools worsen life quality in women with faecal incontinence

Loose stools worsen life quality in women with faecal incontinence

Oncological outcomes in pancreatic cancer similar with less-invasive vs open surgery

Oncological outcomes in pancreatic cancer similar with less-invasive vs open surgery

Lactulose, Tai chi prevent falls in patients with cirrhosis, portal hypertension

Lactulose, Tai chi prevent falls in patients with cirrhosis, portal hypertension

Inebilizumab MITIGATEs flares in IgG4-RD with pancreatic, hepatobiliary involvement

Inebilizumab MITIGATEs flares in IgG4-RD with pancreatic, hepatobiliary involvement

Cilofexor does not halt fibrosis progression in noncirrhotic PSC

Cilofexor does not halt fibrosis progression in noncirrhotic PSC

Vedolizumab better used in early- vs late-stage Crohn’s disease

Vedolizumab better used in early- vs late-stage Crohn’s disease

Does palmitoleic acid supplementation reduce hs-CRP in adults?

Does palmitoleic acid supplementation reduce hs-CRP in adults?