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Esketamine combined with SSRI or SNRI leads to different outcomes in treatment-resistant depression
Esketamine combined with a serotonin-norepinephrine reuptake inhibitor (SNRI) reduces rates of mortality, hospitalizations, and depressive relapses, while esketamine combined with a selective serotonin reuptake inhibitor (SSRI) decreases the incidence of suicidal attempts, a real-world comparative effectiveness study on treatment-resistant depression (TRD) has shown.
Esketamine combined with SSRI or SNRI leads to different outcomes in treatment-resistant depression
30 Apr 2025
Oral microbiota may identify autism in kids with >80 percent accuracy
Eleven oral bacterial species may serve as biomarkers for early detection of autism through simple oral sampling, with an accuracy of 81 percent, according to a cross-disciplinary research team from the Faculty of Dentistry and the Department of Psychology of the University of Hong Kong (HKU).
Oral microbiota may identify autism in kids with >80 percent accuracy
29 Apr 2025
Microdosing LSD fails to reduce symptoms in adult ADHD
Repeated microdosing of lysergic acid diethylamide (LSD) is not more efficacious than placebo in reducing attention-deficit/hyperactivity disorder (ADHD) symptoms in adults, a randomized controlled trial (RCT) has shown.
Microdosing LSD fails to reduce symptoms in adult ADHD
09 Apr 2025
Antidepressant combos deliver improved outcomes in TRD
Combination treatment with esketamine plus either a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) is beneficial in treatment-resistant depression (TRD), with notable variations in outcomes depending on the choice of antidepressant class, as shown in a large retrospective study.