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Which measure of insulin resistance best predicts T2D?
Surrogate indexes calculated from oral glucose tolerance tests (OGTTs) effectively predict the development of type 2 diabetes (T2D), suggests a US study. On the other hand, measures based on fasting insulin are more useful than those that do not measure insulin.
Osilodrostat curbs hypercortisolism in most patients with adrenal CS
Use of osilodrostat is effective at controlling hypercortisolism in one of three (66.7 percent) patients with adrenal Cushing's syndrome (CS) treated for longer than 4 weeks and in nearly four of five (87.5 percent) individuals treated for more than 12 weeks, a real-world study has shown. It also displays a positive impact on blood pressure and body weight.
Do hormonal contraceptives raise CRC risk in premenopausal women?
The use of combined oral contraceptives, progestogen-only pills, or hormonal intrauterine devices neither protects against nor contributes to the risk of colorectal cancer (CRC) in premenopausal women, according to a study.
Which anti-obesity drug is safest, most effective?
Among available drugs for obesity, tirzepatide and cagrilintide-semaglutide (CagriSema) yield the largest decrease in body weight, regardless of diabetes status, suggest the results of a systematic review and network meta-analysis.
Older age, overweight raise risk of symptomatic VTE in DFF patients
A Singapore study has observed a high prevalence of symptomatic venous thromboembolism (VTE) in patients who underwent distal femur fracture (DFF) surgery. Those with advanced age or who are overweight are more likely to develop symptomatic VTE.