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Can indoleacetic acid help overcome P. vulgatus–induced IO resistance in HCC?
Researchers from the University of Hong Kong (HKU) have identified enrichment in Phocaeicola vulgatus as a potential cause for immunotherapy (IO) resistance in patients with hepatocellular carcinoma (HCC) and shown Sthat supplementation with indoleacetic acid (IAA) can overcome P. vulgatus–induced immunosuppression, thereby establishing a causal relationship between P. vulgatus and anti–PD-1 resistance in HCC.
Can indoleacetic acid help overcome P. vulgatus–induced IO resistance in HCC?
25 Nov 2025
Proton therapy for Chinese breast cancer patients: Lower toxicity and significant dosimetric advantage
A single-institution retrospective study comparing proton therapy with conventional radiotherapy using tomotherapy or volumetric modulated arc therapy demonstrated low toxicity and significant dosimetric advantage with proton therapy in Chinese breast cancer patients following definitive surgery, according to data presented at APTCOG-AO 2025 conference held in Hong Kong.
