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Early-phase trial evidence for RRMM treatment highly heterogenous

08 Apr 2021

While early-phase clinical trials may demonstrate substantial levels of overall response rates in patients with relapsed/refractory multiple myeloma (RRMM), high heterogeneity of evidence prevents the accurate assessment of clinical benefit before patient participation, reports a recent meta-analysis.

Early-phase trial evidence for RRMM treatment highly heterogenous

08 Apr 2021

5 patterns of SARS-CoV-2 neutralizing antibody dynamics: What they mean

08 Apr 2021 by

Neutralizing antibody response against SARS-CoV-2 can be categorized into five patterns of response, with persistent neutralizing antibodies being correlated with severe COVID-19 disease and higher pro-inflammatory cytokine levels, according to a Singapore study.

5 patterns of SARS-CoV-2 neutralizing antibody dynamics: What they mean

08 Apr 2021

Pitolisant: New weapon in the battle to stay awake among CPAP-adherent OSA patients

08 Apr 2021 by

The selective histamine H3-receptor antagonist pitolisant appears to quell excessive daytime sleepiness in obstructive sleep apnoea (OSA) patients adherent to continuous positive airway pressure (CPAP) therapy, as shown in a phase III HAROSA I trial.

Pitolisant: New weapon in the battle to stay awake among CPAP-adherent OSA patients

08 Apr 2021

Micronized progesterone improves sleep outcomes in postmenopausal women

08 Apr 2021

Micronized progesterone has been shown to improve sleep outcomes, especially among postmenopausal women, in randomized controlled trials (RCTs), according to the results of a systematic review and meta-analysis.

Micronized progesterone improves sleep outcomes in postmenopausal women

08 Apr 2021

Readmission, death common among COVID-19 patients discharged from hospital

08 Apr 2021 by

Incidence of multiorgan dysfunction is higher among individuals discharged from hospital after COVID-19 than among those in the general population, and this relative risk increase is not confined to the elderly and not uniform across ethnicities, a study has found.

Readmission, death common among COVID-19 patients discharged from hospital

08 Apr 2021

Stuttering teens at higher risk of early-onset T2D

08 Apr 2021

An association has been observed between stuttering in adolescence and an increased risk for early-onset type 2 diabetes (T2D) among men, reports a study.

Stuttering teens at higher risk of early-onset T2D

08 Apr 2021

MCP-1 a promising biomarker for sarcopenic obesity in older adults

08 Apr 2021 by

High levels of the monocyte chemotactic protein-1 (MCP-1) may help identify older adults at risk of sarcopenic obesity, according to a recent Singapore study.

MCP-1 a promising biomarker for sarcopenic obesity in older adults

08 Apr 2021

Prolonged opioid exposure can mess up cognition in seniors

08 Apr 2021

Persistent use of opioids for pain management in older adults may adversely affect their cognitive function, a study has found.

Prolonged opioid exposure can mess up cognition in seniors

08 Apr 2021

Fertility treatment bears no excess breast cancer risk for BRCA1/2 mutation carriers

08 Apr 2021

Among women carrying BRCA1/2 mutation, the use of fertility treatment does not contribute to a discernible increase in breast cancer risk, according to a study.

Fertility treatment bears no excess breast cancer risk for BRCA1/2 mutation carriers

08 Apr 2021

$High-frequency spinal cord stimulation improves pain in refractory painful diabetic neuropathy$

High-frequency spinal cord stimulation improves pain in refractory painful diabetic neuropathy

08 Apr 2021 by

A randomized clinical trial (RCT) in 216 patients with painful diabetic neuropathy (PDN) refractory to ≥1 year of treatment with gabapentinoids and ≥1 other analgesic class shows that high-frequency (10 kHz) spinal cord stimulation (SCS) plus conventional medical management (CMM) is superior to CMM alone in terms of pain relief and health-related quality of life (HRQoL).

High-frequency spinal cord stimulation improves pain in refractory painful diabetic neuropathy

08 Apr 2021

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Early-phase trial evidence for RRMM treatment highly heterogenous

Early-phase trial evidence for RRMM treatment highly heterogenous

5 patterns of SARS-CoV-2 neutralizing antibody dynamics: What they mean

5 patterns of SARS-CoV-2 neutralizing antibody dynamics: What they mean

Pitolisant: New weapon in the battle to stay awake among CPAP-adherent OSA patients

Pitolisant: New weapon in the battle to stay awake among CPAP-adherent OSA patients

Micronized progesterone improves sleep outcomes in postmenopausal women

Micronized progesterone improves sleep outcomes in postmenopausal women

Readmission, death common among COVID-19 patients discharged from hospital

Readmission, death common among COVID-19 patients discharged from hospital

Stuttering teens at higher risk of early-onset T2D

Stuttering teens at higher risk of early-onset T2D

MCP-1 a promising biomarker for sarcopenic obesity in older adults

MCP-1 a promising biomarker for sarcopenic obesity in older adults

Prolonged opioid exposure can mess up cognition in seniors

Prolonged opioid exposure can mess up cognition in seniors

Fertility treatment bears no excess breast cancer risk for BRCA1/2 mutation carriers

Fertility treatment bears no excess breast cancer risk for BRCA1/2 mutation carriers

High-frequency spinal cord stimulation improves pain in refractory painful diabetic neuropathy

High-frequency spinal cord stimulation improves pain in refractory painful diabetic neuropathy