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Enzalutamide improves outcomes in prostate cancer with hrBCR

Treatment with enzalutamide monotherapy demonstrates numerically higher overall survival (OS) in prostate cancer patients with high-risk biochemical recurrence (hrBCR) when compared with leuprolide alone, but the difference is not statistically significant, as shown by the results of the EMBARK study.

Enzalutamide improves outcomes in prostate cancer with hrBCR

22 hours ago

Upadacitinib improves CD, UC in patients with prior tofacitinib failure

23 hours ago

Treatment with upadacitinib induces clinical remission and endoscopic improvement in most patients with severe, refractory Crohn’s disease (CD) or ulcerative colitis (UC) with prior tofacitinib failure, regardless of previous response to tofacitinib, a study has shown.

Upadacitinib improves CD, UC in patients with prior tofacitinib failure

23 hours ago

Acid suppressant use tied to risk of ischaemic events in stroke patients on clopidogrel

a day ago

Acid suppressants such as potassium-competitive acid blockers (P-CABs) and proton pump inhibitors (PPIs), when used concomitantly with clopidogrel, carry an increased risk of ischaemic events in stroke patients, according to a retrospective cohort study.

Acid suppressant use tied to risk of ischaemic events in stroke patients on clopidogrel

a day ago

Less is more in relieving musculoskeletal pain in children

a day ago by

In children with acute nonoperative musculoskeletal injury, treatment with ibuprofen alone appears adequate for relieving pain, with the addition of acetaminophen or hydromorphone yielding no additional analgesic effect, as shown in two No OUCH randomized clinical trials.

Less is more in relieving musculoskeletal pain in children

a day ago

Toxicology service a valuable resource in managing poisoning cases in SG: study

a day ago by

Poisoned individuals form a substantial part of the patient population in Singapore, with prognoses that require early recognition and appropriate measures, according to a study.

Toxicology service a valuable resource in managing poisoning cases in SG: study

a day ago

Tamoxifen use linked to risk of uterine diseases in premenopausal breast cancer patients

23 Mar 2026

Premenopausal breast cancer patients who are receiving tamoxifen as adjuvant hormone therapy appear to be at increased risk of uterine diseases, including endometrial cancer, according to a target trial emulation study from Taiwan.

Tamoxifen use linked to risk of uterine diseases in premenopausal breast cancer patients

23 Mar 2026

Novel antisense oligonucleotide shows disease-modifying potential in Dravet syndrome

21 Mar 2026 by

In children with Dravet syndrome, treatment with the investigational antisense oligonucleotide zorevunersen appears safe and efficacious, with seizure frequency reductions of up to 90 percent and improvements in nonseizure symptoms, according to two phase 1–2a studies (MONARCH and ADMIRAL) and the corresponding open-label extension studies (SWALLOWTAIL and LONGWING).

Novel antisense oligonucleotide shows disease-modifying potential in Dravet syndrome

21 Mar 2026

Non-INSTI-based ART combination on the horizon for broad HIV population

20 Mar 2026 by

The investigational combination of doravirine plus islatravir (DOR/ISL)—a fixed-dose, once-daily oral antiretroviral therapy (ART) regimen that does not rely on integrase strand-transfer inhibitors (INSTIs)—is shaping up to be a promising alternative in the management of HIV, showing noninferiority to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) in individuals initiating treatment for the first time and maintaining virologic suppression in those switching from various ART regimens, as shown in three phase III studies presented at CROI 2026.

Non-INSTI-based ART combination on the horizon for broad HIV population

20 Mar 2026

Xanomeline-trospium chloride combo safe, effective in schizophrenia

20 Mar 2026

Treatment with xanomeline and trospium chloride (X/T) over 52 weeks appears safe and well tolerated, demonstrating durable symptom improvements in individuals with schizophrenia, reports a study.

Xanomeline-trospium chloride combo safe, effective in schizophrenia

20 Mar 2026

How effective are COVID-19 mRNA vaccines in children?

20 Mar 2026 by

Immunization with COVID-19 mRNA vaccines is safe and provides a small protective benefit in children aged 6‒17 years, as shown in a Spain study.

How effective are COVID-19 mRNA vaccines in children?

20 Mar 2026

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Enzalutamide improves outcomes in prostate cancer with hrBCR

Enzalutamide improves outcomes in prostate cancer with hrBCR

Upadacitinib improves CD, UC in patients with prior tofacitinib failure

Upadacitinib improves CD, UC in patients with prior tofacitinib failure

Acid suppressant use tied to risk of ischaemic events in stroke patients on clopidogrel

Acid suppressant use tied to risk of ischaemic events in stroke patients on clopidogrel

Less is more in relieving musculoskeletal pain in children

Less is more in relieving musculoskeletal pain in children

Toxicology service a valuable resource in managing poisoning cases in SG: study

Toxicology service a valuable resource in managing poisoning cases in SG: study

Tamoxifen use linked to risk of uterine diseases in premenopausal breast cancer patients

Tamoxifen use linked to risk of uterine diseases in premenopausal breast cancer patients

Novel antisense oligonucleotide shows disease-modifying potential in Dravet syndrome

Novel antisense oligonucleotide shows disease-modifying potential in Dravet syndrome

Non-INSTI-based ART combination on the horizon for broad HIV population

Non-INSTI-based ART combination on the horizon for broad HIV population

Xanomeline-trospium chloride combo safe, effective in schizophrenia

Xanomeline-trospium chloride combo safe, effective in schizophrenia

How effective are COVID-19 mRNA vaccines in children?

How effective are COVID-19 mRNA vaccines in children?