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Single intranasal dose of live-attenuated vaccine confers broad protection against coronaviruses, including SARS-CoV-2
13 Feb 2026
byNatalia Reoutova
A single intranasal dose of a live-attenuated broad-spectrum coronavirus vaccine developed at the University of Hong Kong (HKU) elicits broad, potent and long-lasting immunity against diverse SARS-CoV-2 variants of concern (VoCs) and more divergent SARS-CoV-1 and hCoV-OC43 that translates into complete protection in animal models, including prevention of viral transmission to unvaccinated contacts.








