News & Updates

Dapagliflozin after TAVI improves outcomes in elderly patients with aortic stenosis

Elderly patients with aortic stenosis who received dapagliflozin after transcatheter aortic-valve implantation (TAVI) had better outcomes than those who did not receive the drug, according to the DapaTAVI* trial presented at ACC.25.

Original New Drug Application Approvals by US FDA (16-31 March 2025)

New drug applications approved by US FDA as of 16-31 March 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Women more likely than men to receive high-intensity statins for secondary prevention post-CABG

Women are more likely than men to fill prescriptions for statin, particularly high-intensity dosages, after undergoing coronary artery bypass surgery (CABG), with statin therapy equally effective at reducing mortality for both sexes, according to a study.

Vaccination crucial to integrated dengue prevention and control in SEA

Southeast Asia (SEA) is one of the hotspots for dengue infections, with Indonesia and Thailand among the highly endemic countries. At a Takeda-sponsored symposium held during the 2nd APIC-ADVA Asia Pacific Summit on Infectious Diseases and Immunization in Singapore, experts focused on vaccination as an integral component of a holistic dengue prevention and control strategy in SEA.

*The editorial below is supported by Takeda Pharmaceuticals International AG Singapore Branch and is intended solely for informational purposes. Takeda has not influenced or contributed to the editorial content. While Takeda has provided financial support for the editorial, Takeda shall not be held responsible or liable for any errors, omissions, or inaccuracies in such information.

Amlodipine makes up half of CCB overdoses; verapamil, diltiazem remain most toxic

Among the cases of calcium channel blocker (CCB) overdose, dihydropyridines are the most common, with amlodipine accounting for nearly half. On the other hand, more severe toxicities occur with the use of verapamil and diltiazem.

What’s new in the 2025 ACS Guidelines?

The American College of Cardiology and the American Heart Association (ACC/AHA) have issued new guidelines for managing acute coronary syndromes (ACS), outlining strategies for lipid management, minimizing bleeding risk, and considerations related to procedural care.

Caution urged when prescribing NSAIDs in pregnancy in relation to kidney health in offspring

Prenatal exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) has the potential to harm the offspring’s kidney health, highlighting the need for caution when prescribing NSAIDs during pregnancy, according to a large study from Taiwan.

Elacestrant shows promising antitumour activity in early breast cancer

Preoperative treatment with the oral nonsteroidal selective ER degrader elacestrant appears to yield biological and molecular responses in early-stage breast cancer, while having a manageable safety profile, as shown in a phase I trial.