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Neuropsychiatric AEs resolve after switch to doravirine-based ARV regimens

10 Sep 2025 by

Switching to a doravirine-based ARV regimen resolves neuropsychiatric AEs that were ongoing during a prior efavirenz-based regimen in DRIVE-AHEAD, with few events persisting 96 weeks after switching — a finding also seen in DRIVE-FORWARD, as shown in post hoc analyses of the OLEs of the two phase III trials

Neuropsychiatric AEs resolve after switch to doravirine-based ARV regimens

10 Sep 2025

Meta-analysis favours clopidogrel over aspirin for secondary prevention in CAD

09 Sep 2025 by

In patients with established coronary artery disease (CAD), clopidogrel appears to provide superior protection against major adverse cardiovascular or cerebrovascular events (MACCE) without increasing the risk of bleeding when compared with aspirin, according to a meta-analysis.

Meta-analysis favours clopidogrel over aspirin for secondary prevention in CAD

09 Sep 2025

Outcomes in ICH patients not different with minimally invasive surgery vs medical management

08 Sep 2025

For patients with supratentorial intracerebral haemorrhage (ICH), minimally invasive surgery is not superior to medical management alone in terms of improving mortality and disability outcomes, according to data from the open-label MIND clinical trial.

Outcomes in ICH patients not different with minimally invasive surgery vs medical management

08 Sep 2025

Short-term exposure to ozone air pollution ups risks of hospital admissions for MI, stroke

07 Sep 2025

Individuals with short-term exposure to ozone (O3) air pollution are at risk of myocardial infarction (MI) and stroke requiring hospitalization, according to a systematic review and meta-analysis.

Short-term exposure to ozone air pollution ups risks of hospital admissions for MI, stroke

07 Sep 2025

What stops patients in SG from getting surgery for drug-resistant epilepsy?

05 Sep 2025 by

Many people with drug-resistant epilepsy in Singapore do not consider surgery because of the overestimated risk of the surgical procedure and the perception that seizures are nondisabling, according to a local cross-sectional survey study.

What stops patients in SG from getting surgery for drug-resistant epilepsy?

05 Sep 2025

Sleep disturbance in epilepsy linked to affective disorders, reduced quality of life

05 Sep 2025

People with epilepsy often experience sleep disturbance, which is linked to other problems such as anxiety and depression and negatively affects quality of life (QoL), according to a study from Germany.

Sleep disturbance in epilepsy linked to affective disorders, reduced quality of life

05 Sep 2025

Awake craniotomy feasible, safe in patients with drug-resistant focal epilepsy

01 Sep 2025

Performing craniotomy for drug-resistant focal epilepsy while a patient is awake appears feasible and does not increase the risk of adverse events, including intraoperative epileptic seizures, according to a retrospective, single-centre cohort study.

Awake craniotomy feasible, safe in patients with drug-resistant focal epilepsy

01 Sep 2025

Morbidity, mortality high in paediatric flu-associated acute necrotizing encephalopathy

31 Aug 2025

Influenza-associated acute necrotizing encephalopathy (ANE) carries increased morbidity and mortality in children, according to a case series.

Morbidity, mortality high in paediatric flu-associated acute necrotizing encephalopathy

31 Aug 2025

Premenopausal bilateral oophorectomy linked to elevated migraine risk

31 Aug 2025

Undergoing bilateral oophorectomy before menopause appears to contribute to an increased risk of migraine, according to a study.

Premenopausal bilateral oophorectomy linked to elevated migraine risk

31 Aug 2025

Familial hypercholesterolemia a risk factor for cerebral small vessel disease

30 Aug 2025

Individuals with familial hypercholesterolemia (FH) appear to be at increased risk of lacunes and cerebral microbleeds, as reported in a study from Japan.

Familial hypercholesterolemia a risk factor for cerebral small vessel disease

30 Aug 2025

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Neuropsychiatric AEs resolve after switch to doravirine-based ARV regimens

Neuropsychiatric AEs resolve after switch to doravirine-based ARV regimens

Meta-analysis favours clopidogrel over aspirin for secondary prevention in CAD

Meta-analysis favours clopidogrel over aspirin for secondary prevention in CAD

Outcomes in ICH patients not different with minimally invasive surgery vs medical management

Outcomes in ICH patients not different with minimally invasive surgery vs medical management

Short-term exposure to ozone air pollution ups risks of hospital admissions for MI, stroke

Short-term exposure to ozone air pollution ups risks of hospital admissions for MI, stroke

What stops patients in SG from getting surgery for drug-resistant epilepsy?

What stops patients in SG from getting surgery for drug-resistant epilepsy?

Sleep disturbance in epilepsy linked to affective disorders, reduced quality of life

Sleep disturbance in epilepsy linked to affective disorders, reduced quality of life

Awake craniotomy feasible, safe in patients with drug-resistant focal epilepsy

Awake craniotomy feasible, safe in patients with drug-resistant focal epilepsy

Morbidity, mortality high in paediatric flu-associated acute necrotizing encephalopathy

Morbidity, mortality high in paediatric flu-associated acute necrotizing encephalopathy

Premenopausal bilateral oophorectomy linked to elevated migraine risk

Premenopausal bilateral oophorectomy linked to elevated migraine risk

Familial hypercholesterolemia a risk factor for cerebral small vessel disease

Familial hypercholesterolemia a risk factor for cerebral small vessel disease