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Investigational triple–hormone-receptor agonist reduces fat mass in people with T2D

10 Jul 2025

Treatment with retatrutide—an agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors—appears to result in greater total body fat mass reduction in individuals with type 2 diabetes (T2D) and high BMI when compared with placebo and dulaglutide, according to a substudy of a phase II trial.

Investigational triple–hormone-receptor agonist reduces fat mass in people with T2D

10 Jul 2025

ADHD medications’ real-world benefits diminish as prescription rate rises

10 Jul 2025 by

Attention-deficit/hyperactivity disorder (ADHD) medications are associated with reduced risks of several serious real-world outcomes, but the magnitude of these associations has decreased alongside rising prescription rates, a nationwide study has shown.

ADHD medications’ real-world benefits diminish as prescription rate rises

10 Jul 2025

Pembrolizumab + CCRT ups survival in high-risk LACC

10 Jul 2025 by

Treatment with the combination of pembrolizumab and concurrent chemoradiotherapy (CCRT), followed by pembrolizumab maintenance, led to a sustained, long-term survival benefit in patients with high-risk, locally advanced cervical cancer (LACC) compared with CCRT alone, according to the final analysis of the phase III ENGOT-cx11/GOG-3047/KEYNOTE-A18 trial presented at ASCO 2025.

Pembrolizumab + CCRT ups survival in high-risk LACC

10 Jul 2025

SGLT-2 inhibitors may provide liver-related benefits to patients with cirrhosis

09 Jul 2025 by

The use of a sodium-glucose cotransporter 2 (SGLT-2) inhibitor helps lower the incidence of serious liver events among patients with cirrhosis who are receiving diuretic therapy, according to a study.

SGLT-2 inhibitors may provide liver-related benefits to patients with cirrhosis

09 Jul 2025

Does testosterone level predict metastasis-free survival in nmCRPC?

09 Jul 2025

Maintenance serum testosterone levels ≥20 ng/dL do not appear predictive of worse metastasis-free survival (MFS) among men with testosterone <50 ng/dL on first-line therapy of nonmetastatic castration-resistant prostate cancer (nmCRPC) using novel hormonal agents, according to a study.

Does testosterone level predict metastasis-free survival in nmCRPC?

09 Jul 2025

Malays most referred patients to nephrology care in SG

09 Jul 2025 by

A Singapore study has found that patients referred for kidney disease are predominantly Malays, who tend to have higher metabolic disease burden, miss their appointments, and be referred at lower estimated glomerular filtration rate (eGFR).

Malays most referred patients to nephrology care in SG

09 Jul 2025

Defibrillation testing may be omitted in most recipients of S-ICD

09 Jul 2025

The majority of subcutaneous implantable cardioverter defibrillator (S-ICD) recipients may safely forgo defibrillation testing (DT) during implantation, suggests a study. However, selective DT may be considered in those at higher risk.

Defibrillation testing may be omitted in most recipients of S-ICD

09 Jul 2025

Oral mitapivat beneficial in the treatment of non-transfusion-dependent thalassaemia

09 Jul 2025

Mitapivat, an oral activator of pyruvate kinase, appears to increase haemoglobin concentration and improve fatigue in adults with non-transfusion-dependent (NTD) α-thalassaemia or NTD β-thalassaemia, according to the double-blind phase III ENERGIZE study.

Oral mitapivat beneficial in the treatment of non-transfusion-dependent thalassaemia

09 Jul 2025

Structured exercise after adjuvant chemotherapy for colon cancer extend overall survival

09 Jul 2025 by

A structured exercise programme offered alongside health education materials may prolong overall survival (OS) in patients with resected colon cancer who have completed adjuvant chemotherapy, according to the final results of the phase III CHALLENGE trial presented at ASCO 2025.

Structured exercise after adjuvant chemotherapy for colon cancer extend overall survival

09 Jul 2025

Trifarotene: Acne Relieve by Modern Retinoid Molecule

09 Jul 2025 by

สิวที่หลังมักถูกมองข้ามแต่มีผลกระทบต่อคุณภาพชีวิตและความมั่นใจไม่น้อยไปกว่าสิวบนใบหน้า การรักษาเน้นการใช้ยาทากลุ่ม retinoids เป็นตัวเลือกแรก โดย trifarotene เป็น retinoid รุ่นที่ 4 ออกฤทธิ์จำเพาะต่อ RAR-γ มีประสิทธิภาพสูงในการรักษาสิวทั้งบริเวณใบหน้าและลำตัวแม้ในความเข้มข้นต่ำ สามารถลดจำนวนสิวได้ตั้งแต่ 2 สัปดาห์แรก และช่วยลดรอยหลุมสิวและรอยแผลเป็นได้ดีกว่า vehicle cream แม้อาจพบอาการระคายเคืองได้ในช่วงแรก แต่จะลดลงได้เมื่อใช้อย่างต่อเนื่อง และสามารถจัดการได้ด้วยการใช้ผลิตภัณฑ์ดูแลผิวที่เหมาะสม ยา trifarotene จึงมีศักยภาพในการรักษาสิวระดับเล็กน้อยถึงปานกลาง และมีความปลอดภัยในการใช้ระยะยาว

Trifarotene: Acne Relieve by Modern Retinoid Molecule

09 Jul 2025

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Investigational triple–hormone-receptor agonist reduces fat mass in people with T2D

Investigational triple–hormone-receptor agonist reduces fat mass in people with T2D

ADHD medications’ real-world benefits diminish as prescription rate rises

ADHD medications’ real-world benefits diminish as prescription rate rises

Pembrolizumab + CCRT ups survival in high-risk LACC

Pembrolizumab + CCRT ups survival in high-risk LACC

SGLT-2 inhibitors may provide liver-related benefits to patients with cirrhosis

SGLT-2 inhibitors may provide liver-related benefits to patients with cirrhosis

Does testosterone level predict metastasis-free survival in nmCRPC?

Does testosterone level predict metastasis-free survival in nmCRPC?

Malays most referred patients to nephrology care in SG

Malays most referred patients to nephrology care in SG

Defibrillation testing may be omitted in most recipients of S-ICD

Defibrillation testing may be omitted in most recipients of S-ICD

Oral mitapivat beneficial in the treatment of non-transfusion-dependent thalassaemia

Oral mitapivat beneficial in the treatment of non-transfusion-dependent thalassaemia

Structured exercise after adjuvant chemotherapy for colon cancer extend overall survival

Structured exercise after adjuvant chemotherapy for colon cancer extend overall survival

Trifarotene: Acne Relieve by Modern Retinoid Molecule

Trifarotene: Acne Relieve by Modern Retinoid Molecule