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No APHINITY between statin use and survival outcomes in early HER2-positive breast cancer
Statin use was not associated with improved survival outcomes in the phase III APHINITY trial investigating the addition of pertuzumab to trastuzumab and chemotherapy as adjuvant treatment for patients with early HER2-positive breast cancer (BC).
No APHINITY between statin use and survival outcomes in early HER2-positive breast cancer
26 May 2025
Full-spectrum microbiome drug for IBS with constipation clears phase II trial
The next-generation oral full-spectrum microbiome drug EBX-102-02 appears to have an acceptable safety profile in patients with irritable bowel syndrome with constipation (IBS-C) while yielding improvements in symptom severity, abdominal pain, and stool consistency, according to the results of the phase IIa TrIuMPH* study.
Full-spectrum microbiome drug for IBS with constipation clears phase II trial
25 May 2025
Linerixibat quells cholestatic itch in PBC, enabling better sleep
The ileal bile acid transporter inhibitor linerixibat provides rapid and substantial relief from cholestatic pruritus, in turn reducing associated sleep disturbances, in patients with primary biliary cholangitis (PBC), as shown in the global, phase III GLISTEN trial.