News & Updates

MTX plus MMI for Graves’ disease tied to higher discontinuation rate

03 Feb 2025

The addition of low-dose methotrexate (MTX) to methimazole (MMI) shows a higher rate of discontinuation than MMI alone, as well as significant reductions in thyrotropin-related antibodies (TRAb) levels, in patients with Graves’ disease (GD), reveals a study.

MTX plus MMI for Graves’ disease tied to higher discontinuation rate

03 Feb 2025

Dupilumab trumps MTX, cyclosporine in paediatric AD

03 Feb 2025 by

The use of dupilumab in children with moderate-to-severe atopic dermatitis (AD) results in greater improvements in AD severity, better adherence, and fewer treatment-emergent adverse events (TEAEs) than methotrexate (MTX) or cyclosporine, as shown by 2-year interim results from the PEDISTAD study.

Dupilumab trumps MTX, cyclosporine in paediatric AD

03 Feb 2025

Transdermal microneedle less painful vs intralesional injection in AA

03 Feb 2025

In the treatment of mild-to-moderate patchy alopecia areata (AA), microneedle transdermal delivery of compound betamethasone exhibits similar efficacy as the traditional intralesional injection and a significant reduction in pain, according to a study.

Transdermal microneedle less painful vs intralesional injection in AA

03 Feb 2025

Add-on tiragolumab improves antitumour response in unresectable HCC

03 Feb 2025

In the treatment of patients with unresectable hepatocellular carcinoma (HCC), the addition of tiragolumab to atezolizumab plus bevacizumab yields meaningful improvements in antitumour response and disease control, according to data from an open-label phase 1b–2 study.

Add-on tiragolumab improves antitumour response in unresectable HCC

03 Feb 2025

Experimental HPV vaccine shrinks high-grade precancerous cervical lesions

02 Feb 2025 by

A novel vaccine that targets HPV type 16 (HPV16) has shown clinical activity against HPV16-positive cervical intraepithelial neoplasia grade 3 (CIN3) in a phase II trial, substantially reducing lesion size.

Experimental HPV vaccine shrinks high-grade precancerous cervical lesions

02 Feb 2025

Does sacubitril-valsartan plus spironolactone induce ADRs?

02 Feb 2025

Treatment with the combination of sacubitril-valsartan plus spironolactone during hospitalization for acute decompensated heart failure (ADHF) does not lead to a substantially higher incidence of adverse drug reactions (ADRs), a study has shown.

Does sacubitril-valsartan plus spironolactone induce ADRs?

02 Feb 2025

Baricitinib plus phototherapy shows potential against extensive vitiligo

01 Feb 2025

Treatment with the combination of the small molecule Janus kinase 1/2 inhibitor baricitinib plus phototherapy may help reduce disease activity and induce repigmentation in adults with extensive and active nonsegmental vitiligo, according to the results of a phase II study.

Baricitinib plus phototherapy shows potential against extensive vitiligo

01 Feb 2025

Antipsychotic adherence helps keep lid on suicidal behaviour

01 Feb 2025 by

Ensuring antipsychotic medication use as prescribed may be crucial for reducing the risk of suicidality among patients with schizophrenia, according to a study.

Antipsychotic adherence helps keep lid on suicidal behaviour

01 Feb 2025

Clozapine tied to haematological malignancy in schizophrenia

01 Feb 2025 by

The use of clozapine appears to slightly increase the risk of haematological malignancy (HM) among patients with schizophrenia compared with olanzapine use, suggests a study.

Clozapine tied to haematological malignancy in schizophrenia

01 Feb 2025

Prourokinase does not improve functional outcomes in mild ischaemic stroke

31 Jan 2025

In the treatment of patients with mild ischaemic stroke, prourokinase is not necessarily better than standard of care in terms of improving functional outcomes, although both have a similar safety profile, according to a study.

Prourokinase does not improve functional outcomes in mild ischaemic stroke

31 Jan 2025

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MTX plus MMI for Graves’ disease tied to higher discontinuation rate

MTX plus MMI for Graves’ disease tied to higher discontinuation rate

Dupilumab trumps MTX, cyclosporine in paediatric AD

Dupilumab trumps MTX, cyclosporine in paediatric AD

Transdermal microneedle less painful vs intralesional injection in AA

Transdermal microneedle less painful vs intralesional injection in AA

Add-on tiragolumab improves antitumour response in unresectable HCC

Add-on tiragolumab improves antitumour response in unresectable HCC

Experimental HPV vaccine shrinks high-grade precancerous cervical lesions

Experimental HPV vaccine shrinks high-grade precancerous cervical lesions

Does sacubitril-valsartan plus spironolactone induce ADRs?

Does sacubitril-valsartan plus spironolactone induce ADRs?

Baricitinib plus phototherapy shows potential against extensive vitiligo

Baricitinib plus phototherapy shows potential against extensive vitiligo

Antipsychotic adherence helps keep lid on suicidal behaviour

Antipsychotic adherence helps keep lid on suicidal behaviour

Clozapine tied to haematological malignancy in schizophrenia

Clozapine tied to haematological malignancy in schizophrenia

Prourokinase does not improve functional outcomes in mild ischaemic stroke

Prourokinase does not improve functional outcomes in mild ischaemic stroke