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EPIK-B5 supports alpelisib plus fulvestrant for HR+, HER2– ABC

15 Jan 2026 bởi

In the phase III EPIK-B5 study, adding alpelisib, an α-specific PI3K inhibitor, to fulvestrant improves progression-free survival (PFS) in men and postmenopausal women with HR+, HER2− advanced breast cancer (ABC) harbouring a PIK3CA mutation who have progressed on or after treatment with an aromatase inhibitor (AI) and a CDK4/6 inhibitor (CDK4/6i).

EPIK-B5 supports alpelisib plus fulvestrant for HR+, HER2– ABC

15 Jan 2026

Frontline anlotinib-containing regimen shows promise in advanced soft-tissue sarcoma

14 Jan 2026

In the treatment of patients with advanced soft-tissue sarcoma, combining anlotinib with anthracyclines and ifosfamide in the first-line setting followed by anlotinib maintenance has demonstrated promising efficacy, with acceptable toxicities, in a phase II study.

Frontline anlotinib-containing regimen shows promise in advanced soft-tissue sarcoma

14 Jan 2026

Novel syringe improves HCP experience during aspiration

14 Jan 2026 bởi

A novel syringe demonstrates better user experience than a hypodermic syringe during aspiration by standardizing the process, regardless of user, drug type, volume, or injection site, reports a study.

Novel syringe improves HCP experience during aspiration

14 Jan 2026

Sử dụng glucocorticoid trước sinh khiến trẻ dễ mắc các rối loạn tâm thần

14 Jan 2026

Theo một nghiên cứu đoàn hệ quy mô lớn, phụ nữ mang thai sử dụng glucocorticoid có thể khiến trẻ có nguy cơ mắc một số rối loạn tâm thần.

Sử dụng glucocorticoid trước sinh khiến trẻ dễ mắc các rối loạn tâm thần

14 Jan 2026

Z-drug exposure during early pregnancy not a risk factor for congenital malformations

14 Jan 2026

The use of nonbenzodiazepine sedative hypnotics (Z-drugs) for sleep dysregulation during the first trimester of pregnancy does not appear to contribute to a meaningful increase in the risk of congenital malformations overall, as shown in a study.

Z-drug exposure during early pregnancy not a risk factor for congenital malformations

14 Jan 2026

Omega-3 fatty acid supplementation does nothing for youths with depression

13 Jan 2026

In the treatment of children and adolescents with major depressive disorder (MDD), adjunctive supplementation with omega-3 fatty acid does not appear to significantly improve outcomes compared with placebo, according to study.

Omega-3 fatty acid supplementation does nothing for youths with depression

13 Jan 2026

Sooner is better when initiating DAPT after minor stroke or high-risk TIA

12 Jan 2026

Initiating dual antiplatelet therapy (DAPT) within 24 h of onset of a minor ischaemic stroke or transient ischaemic attack (TIA) yields the greatest clinical benefit, with the therapeutic effect declining progressively beyond this period, as shown in a study.

Sooner is better when initiating DAPT after minor stroke or high-risk TIA

12 Jan 2026

Long-term use of mirikizumab does not raise new safety signals

11 Jan 2026 bởi

A recent study has demonstrated the long-term safety of mirikizumab in patients with moderate to severe active ulcerative colitis (UC), with no new significant safety concerns.

Long-term use of mirikizumab does not raise new safety signals

11 Jan 2026

Synbiotics beneficial to older adults with diabetes

11 Jan 2026

A multi-species synbiotic preparation appears to improve outcomes in older patients with type 2 diabetes mellitus and high cardiovascular risk, according to a study.

Synbiotics beneficial to older adults with diabetes

11 Jan 2026

Patient fatigue flags risk of toxicity from cancer treatment

10 Jan 2026 bởi

Patient fatigue reported before the initiation of cancer treatment appears to be associated with an increased risk of subsequent treatment-related adverse events, according to new research.

Patient fatigue flags risk of toxicity from cancer treatment

10 Jan 2026

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EPIK-B5 supports alpelisib plus fulvestrant for HR+, HER2– ABC

EPIK-B5 supports alpelisib plus fulvestrant for HR+, HER2– ABC

Frontline anlotinib-containing regimen shows promise in advanced soft-tissue sarcoma

Frontline anlotinib-containing regimen shows promise in advanced soft-tissue sarcoma

Novel syringe improves HCP experience during aspiration

Novel syringe improves HCP experience during aspiration

Sử dụng glucocorticoid trước sinh khiến trẻ dễ mắc các rối loạn tâm thần

Sử dụng glucocorticoid trước sinh khiến trẻ dễ mắc các rối loạn tâm thần

Z-drug exposure during early pregnancy not a risk factor for congenital malformations

Z-drug exposure during early pregnancy not a risk factor for congenital malformations

Omega-3 fatty acid supplementation does nothing for youths with depression

Omega-3 fatty acid supplementation does nothing for youths with depression

Sooner is better when initiating DAPT after minor stroke or high-risk TIA

Sooner is better when initiating DAPT after minor stroke or high-risk TIA

Long-term use of mirikizumab does not raise new safety signals

Long-term use of mirikizumab does not raise new safety signals

Synbiotics beneficial to older adults with diabetes

Synbiotics beneficial to older adults with diabetes

Patient fatigue flags risk of toxicity from cancer treatment

Patient fatigue flags risk of toxicity from cancer treatment