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The combination of chemotherapy and anti-EGFR/BRAF therapy provides optimal survival benefits to patients with advanced BRAF-mutated colorectal cancer (CRC), according to a study.

Chemo plus targeted therapy extends survival in advanced BRAF-mutated CRC

16 Dec 2025

Add-on ON101 cost-effective for DFUs

An economic analysis shows the cost-effectiveness of adding ON101 to general wound care (GWC) for the treatment of diabetic foot ulcers (DFUs) in individuals with type 2 diabetes (T2D) in Singapore, with robust results across subgroup and sensitivity analyses.

Add-on ON101 cost-effective for DFUs

16 Dec 2025

Tinengotinib shows promising activity against cholangiocarcinoma

In patients with cholangiocarcinoma with FGFR2 fusions that progressed following FGFR inhibitor therapy, tinengotinib has demonstrated potential antitumour activity in a phase II study.

Tinengotinib shows promising activity against cholangiocarcinoma

Oral PCSK9 inhibitor lowers LDL-C by up to 60 percent

The oral PCSK9 inhibitor enlicitide lowers LDL-cholesterol (LDL-C) levels and other atherogenic lipids in high-risk patients with hypercholesterolaemia, as shown in the CORALreef Lipids study presented at AHA 2025.

Oral PCSK9 inhibitor lowers LDL-C by up to 60 percent

Deaths from C. difficile higher in women, White patients

Despite advances in infection control and antimicrobial stewardship, mortality from Clostridioides difficile (C. difficile) enterocolitis continues to disproportionately affect certain populations in the US, according to an analysis of the CDC WONDER database presented at IDWeek 2025.

Deaths from C. difficile higher in women, White patients

HFrEF outcomes due to Chagas disease no better with sacubitril/valsartan vs enalapril

In the treatment of patients with heart failure with reduced ejection fraction (HFrEF) secondary to Chagas disease, the use of sacubitril/valsartan does not appear to lead to improvements in clinical outcomes compared with enalapril, according to a study.

HFrEF outcomes due to Chagas disease no better with sacubitril/valsartan vs enalapril

Laughing gas touted as rapid-acting antidepressant in meta-analysis

15 Dec 2025 bởi

Administration of nitrous oxide (N2O) appears to alleviate depressive symptoms as quickly as 2 h, according to a meta-analysis.

Laughing gas touted as rapid-acting antidepressant in meta-analysis

Inebilizumab MITIGATEs flares in IgG4-RD with pancreatic, hepatobiliary involvement

15 Dec 2025 bởi

The post hoc subgroup analysis of the phase III MITIGATE trial shows the benefit of the humanized monoclonal anti-CD19 antibody inebilizumab in adults with IgG4-related disease (IgG4-RD) with pancreas, bile duct, and liver involvement at baseline.

Inebilizumab MITIGATEs flares in IgG4-RD with pancreatic, hepatobiliary involvement

Rethinking pharmacy practice to support patient self-care

In a recent webinar, Kenvue brought together leading healthcare professionals to share their expertise and highlight the vital role of pharmacists in patient-centered care. Mr John Bell, Principal Advisor of the Pharmaceutical Society of Australia Self-Care Program, described pharmacists as key enablers of self-care. Dr Karthick Annamalai, a Consultant Paediatrician and Neonatologist at Coimbatore Children’s Hospital, India, offered insights into managing paediatric sensitive skin and atopic dermatitis. Dr Leona Yip, Founding Partner and Director, Skin Partners, Brisbane, Australia, focused on skincare for Gen Z. Dr Jose Angelo Militante, Chairman of the General Dental Practice of the Asia Pacific Dental Federation, Philippines, discussed the importance of incorporating mouthwash into oral care.

Rethinking pharmacy practice to support patient self-care