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Cigarette smoking strongly contributes to the development of cardiovascular (CV) disease, with a recent study showing dose-response relationships of smoking-relevant parameters across three domains of subclinical markers of CV harm.

Smoking tied to subclinical markers of CV harm

Alternating R-DA-EDOCH/R-DHAP induces deep remission in young Chinese patients with MCL

23 Mar 2025 bởi

A phase III trial demonstrated a high minimal residual disease (MRD)-negativity rate with intensive continuous dose-adjusted rituximab plus etoposide, dexamethasone, doxorubicin, cyclophosphamide, and vincristine (R-DA-EDOCH) alternated with rituximab, dexamethasone, cytarabine, and cisplatin (R-DHAP), thereby offering an alternative induction therapy choice for young Chinese patients with mantle-cell lymphoma (MCL).

Alternating R-DA-EDOCH/R-DHAP induces deep remission in young Chinese patients with MCL

Curcumin reduces vincristine-induced neuropathy in paediatric ALL

23 Mar 2025 bởi

A double-blind randomized controlled trial (RCT) reports a significantly lower incidence of vincristine-induced peripheral neuropathy (VIPN) in paediatric acute lymphoblastic leukaemia (ALL) patients who received curcumin vs placebo.

Curcumin reduces vincristine-induced neuropathy in paediatric ALL

SGLT2 inhibitors easy on the kidneys of Asians with T2D

22 Mar 2025 bởi

Among Asians with type 2 diabetes (T2D), users of sodium-glucose cotransporter-2 (SGLT2) inhibitors may have better kidney outcomes compared with those who use other glucose-lowering drugs.

SGLT2 inhibitors easy on the kidneys of Asians with T2D

22 Mar 2025

Vegetable oil use may prevent body fat accumulation in young adulthood

A recent study has shown the inverse associations of plasma phospholipid proportions of linoleic acid (LA) and α-linolenic acid (ALA), biomarkers of vegetable oil intake, during childhood and adolescence with measures of obesity and cardiometabolic health in young adulthood. A potential sex difference has also been observed.

Vegetable oil use may prevent body fat accumulation in young adulthood

Personalized exercise intervention beneficial to lung cancer patients

A personalized, perioperative, home-based exercise intervention for patients undergoing lung cancer helps improve physical function in women and prevent fatigue worsening in all groups, according to the results of the phase III Precision-Exercise-Prescription (PEP) trial.

Personalized exercise intervention beneficial to lung cancer patients

Poor sleep worsens knee pain in young adults

Knee pain in young adults appears to be aggravated by sleep disturbances, as suggested in a study.

Poor sleep worsens knee pain in young adults

Lignan intake helps prevent CVD, cancer deaths in diabetic adults

Increased consumption of lignans, specifically secoisolariciresinol (SECO), results in a significant reduction in overall cardiovascular disease (CVD) and cancer mortality among individuals with type 2 diabetes (T2D), a study has shown.

Lignan intake helps prevent CVD, cancer deaths in diabetic adults

Ensitrelvir safe, effective in preventing COVID-19 in households

21 Mar 2025 bởi

Treatment with ensitrelvir among household contacts (HHC) of index patients (IP) with COVID-19 within 72 h after the onset of IP symptoms demonstrates efficacy and an acceptable safety profile as postexposure prophylaxis (PEP) in SCORPIO-PEP, a phase III placebo-controlled trial.

Ensitrelvir safe, effective in preventing COVID-19 in households

21 Mar 2025

Is it safe to stop taking digoxin in HFrEF patients on beta-blockers?

Patients with heart failure (HF) with reduced ejection fraction (HFrEF) who are taking beta-blockers may discontinue using digoxin without putting themselves at greater risk of adverse outcomes, suggest the results of the OPTIMIZE-HF study.

Is it safe to stop taking digoxin in HFrEF patients on beta-blockers?