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Intra-arterial alteplase increases likelihood of excellent post-thrombectomy functional outcome

05 Nov 2025 bởi

Intra-arterial alteplase (IAA) resulted in a higher likelihood of excellent functional outcome at 90 days among patients with acute, anterior-circulation, large-vessel occlusion (LVO) stroke who achieved successful endovascular reperfusion by mechanical thrombectomy, a study in China has found.

Intra-arterial alteplase increases likelihood of excellent post-thrombectomy functional outcome

05 Nov 2025

Gene variant in Chinese linked to higher Alzheimer’s risk and more severe pathology

05 Nov 2025 bởi

The TREM2 H157Y variant gene significantly increases the risk of Alzheimer’s disease (AD) in ethnic Chinese and is associated with more rapid clinical progression and more severe neurodegeneration, researchers from the Hong Kong University of Science and Technology (HKUST) have found.

Gene variant in Chinese linked to higher Alzheimer’s risk and more severe pathology

05 Nov 2025

Pre-op tiragolumab plus atezolizumab viable in advanced NSCLC

04 Nov 2025 bởi

Neoadjuvant treatment with tiragolumab plus atezolizumab, with or without chemotherapy, is feasible in advanced resectable non-small cell lung cancer (NSCLC), having an acceptable safety profile and yielding major pathologic response (MPR) rates comparable to that observed with other perioperative immunotherapy plus chemotherapy regimens, according to the phase II SKYSCRAPER-05 trial.

Pre-op tiragolumab plus atezolizumab viable in advanced NSCLC

04 Nov 2025

DNMT3A mutations predict PD-(L)1 blockade efficacy in NSCLC

04 Nov 2025

Some patients with nonsmall-cell lung cancer (NSCLC) have somatic DNA methyltransferase 3A (DNMT3A) mutations, which are associated with a reduced DNMT3A expression and a favourable immunophenotype, reveals a study.

DNMT3A mutations predict PD-(L)1 blockade efficacy in NSCLC

04 Nov 2025

SGLT-2i lowers autoimmune rheumatic disease risk in T2D

04 Nov 2025 bởi

The use of sodium-glucose cotransporter-2 (SGLT-2) inhibitors, compared with sulfonylureas, results in a reduced risk of autoimmune rheumatic disease among adults with type 2 diabetes (T2D), reports a recent study.

SGLT-2i lowers autoimmune rheumatic disease risk in T2D

04 Nov 2025

Which exercise works best for people with knee OA?

04 Nov 2025 bởi

Aerobic exercise appears to be the best form of workout for people with knee osteoarthritis (OA), resulting in improved pain, function, gait performance, and quality of life (QoL), suggests a study.

Which exercise works best for people with knee OA?

04 Nov 2025

Shift work a risk factor for kidney stones

04 Nov 2025 bởi

A recent study suggests a positive association between shift work and risk of kidney stone events, with lifestyle factors partially mediating the association.

Shift work a risk factor for kidney stones

04 Nov 2025

Heart failure outcomes better with nonsteroidal vs steroidal MRAs

04 Nov 2025

In the treatment of patients with heart failure, the use of nonsteroidal mineralocorticoid receptor antagonists (MRAs) such as finerenone appears to improve clinical outcomes compared with steroidal MRAs, as shown in a retrospective study.

Heart failure outcomes better with nonsteroidal vs steroidal MRAs

04 Nov 2025

Semaglutide safe for dialysis patients in pooled analysis

04 Nov 2025 bởi

Treatment with the GLP-1 receptor agonist semaglutide appears safe for patients initiating dialysis, as demonstrated in a pooled analysis presented at EASD 2025.

Semaglutide safe for dialysis patients in pooled analysis

04 Nov 2025

Seizures common in congenital heart disease

03 Nov 2025

Infants appear to have a more than fivefold greater odds of experiencing seizures in the presence of congenital heart disease (CHD), according to a study.

Seizures common in congenital heart disease

03 Nov 2025

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Intra-arterial alteplase increases likelihood of excellent post-thrombectomy functional outcome

Intra-arterial alteplase increases likelihood of excellent post-thrombectomy functional outcome

Gene variant in Chinese linked to higher Alzheimer’s risk and more severe pathology

Gene variant in Chinese linked to higher Alzheimer’s risk and more severe pathology

Pre-op tiragolumab plus atezolizumab viable in advanced NSCLC

Pre-op tiragolumab plus atezolizumab viable in advanced NSCLC

DNMT3A mutations predict PD-(L)1 blockade efficacy in NSCLC

DNMT3A mutations predict PD-(L)1 blockade efficacy in NSCLC

SGLT-2i lowers autoimmune rheumatic disease risk in T2D

SGLT-2i lowers autoimmune rheumatic disease risk in T2D

Which exercise works best for people with knee OA?

Which exercise works best for people with knee OA?

Shift work a risk factor for kidney stones

Shift work a risk factor for kidney stones

Heart failure outcomes better with nonsteroidal vs steroidal MRAs

Heart failure outcomes better with nonsteroidal vs steroidal MRAs

Semaglutide safe for dialysis patients in pooled analysis

Semaglutide safe for dialysis patients in pooled analysis

Seizures common in congenital heart disease

Seizures common in congenital heart disease