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Steroidal mineralocorticoid receptor antagonist offers no CV mortality benefit in dialysis patients

28 Aug 2025

Treatment with steroidal mineralocorticoid receptor antagonists does not appear to provide significant protection against cardiovascular mortality in patients undergoing dialysis, as shown in a systematic review and meta-analysis.

Steroidal mineralocorticoid receptor antagonist offers no CV mortality benefit in dialysis patients

28 Aug 2025

Mild behavioural impairment a warning signal for neurodegeneration

28 Aug 2025 bởi

People who report symptoms of mild behavioural impairment exhibit pronounced cortical thinning in regions involved in emotion regulation, belief formation, and cognitive control in the right side of the brain, according to a study.

Mild behavioural impairment a warning signal for neurodegeneration

28 Aug 2025

Rituximab not superior to conventional therapy in EGPA

28 Aug 2025

The use of rituximab falls short of demonstrating superiority over a conventional remission induction strategy in patients diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA), reveals a study.

Rituximab not superior to conventional therapy in EGPA

28 Aug 2025

Does hyperaldosteronism drive increased salt-sensitive BP in women?

28 Aug 2025 bởi

Salt-sensitive blood pressure (SSBP), aldosterone response to angiotensin II, and aldosterone/plasma renin activity (PRA) ratios are all greater in women than in men, suggests a study. However, men show higher levels of basal aldosterone and its secretagogues.

Does hyperaldosteronism drive increased salt-sensitive BP in women?

28 Aug 2025

Exercise plus diet reduces weight, but does little to improve hip pain

28 Aug 2025

The addition of a weight-loss diet to exercise does not appear to change hip pain severity, in adults with hip osteoarthritis and overweight or obesity. However, it results in improvements in most other outcomes such as body weight and body composition.

Exercise plus diet reduces weight, but does little to improve hip pain

28 Aug 2025

Should O2 exposure be reduced in critically ill patients on MV, O2?

28 Aug 2025 bởi

Findings from the UK-ROX* trial do not support reducing oxygen (O2) exposure by targeting a peripheral O2 saturation (SpO2) of 90 percent in adult patients receiving mechanical ventilation (MV) and supplemental O2 in the intensive care unit (ICU).

Should O2 exposure be reduced in critically ill patients on MV, O2?

28 Aug 2025

Adequate sleep, exercise reduce mortality in individuals with depression

28 Aug 2025

Getting enough sleep, engaging in high levels of physical activity, and cutting sedentary time appear to lower the risk of mortality in people with depression, according to a study.

Adequate sleep, exercise reduce mortality in individuals with depression

28 Aug 2025

Statin exposure associated with longer OS in apalutamide-treated patients with advanced prostate cancer

28 Aug 2025 bởi

A study using individual patient data from the SPARTAN and TITAN randomized clinical trials has found that statin exposure was associated with superior overall survival (OS) among all patients with advanced prostate cancer (PC) who were treated with apalutamide.

Statin exposure associated with longer OS in apalutamide-treated patients with advanced prostate cancer

28 Aug 2025

Does adjuvant aspirin have a protective effect in resected PIK3CA-mutant colon cancer?

28 Aug 2025 bởi

Adjuvant aspirin is associated with clinically relevant disease-free survival (DFS) and time to disease recurrence (TTR) improvements, according to a phase III randomized, placebo-controlled trial.

Does adjuvant aspirin have a protective effect in resected PIK3CA-mutant colon cancer?

28 Aug 2025

Certain nonsurgical interventions for chronic low back pain may offer sustained benefits

27 Aug 2025

For individuals with chronic low back pain, nonsurgical interventions such as cognitive behavioural therapy (CBT), mindfulness, exercise, and multidisciplinary care can help reduce pain intensity and disability in the long term, according to a systematic review and meta-analysis.

Certain nonsurgical interventions for chronic low back pain may offer sustained benefits

27 Aug 2025

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Steroidal mineralocorticoid receptor antagonist offers no CV mortality benefit in dialysis patients

Steroidal mineralocorticoid receptor antagonist offers no CV mortality benefit in dialysis patients

Mild behavioural impairment a warning signal for neurodegeneration

Mild behavioural impairment a warning signal for neurodegeneration

Rituximab not superior to conventional therapy in EGPA

Rituximab not superior to conventional therapy in EGPA

Does hyperaldosteronism drive increased salt-sensitive BP in women?

Does hyperaldosteronism drive increased salt-sensitive BP in women?

Exercise plus diet reduces weight, but does little to improve hip pain

Exercise plus diet reduces weight, but does little to improve hip pain

Should O2 exposure be reduced in critically ill patients on MV, O2?

Should O2 exposure be reduced in critically ill patients on MV, O2?

Adequate sleep, exercise reduce mortality in individuals with depression

Adequate sleep, exercise reduce mortality in individuals with depression

Statin exposure associated with longer OS in apalutamide-treated patients with advanced prostate cancer

Statin exposure associated with longer OS in apalutamide-treated patients with advanced prostate cancer

Does adjuvant aspirin have a protective effect in resected PIK3CA-mutant colon cancer?

Does adjuvant aspirin have a protective effect in resected PIK3CA-mutant colon cancer?

Certain nonsurgical interventions for chronic low back pain may offer sustained benefits

Certain nonsurgical interventions for chronic low back pain may offer sustained benefits