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Antipsychotic drugs tied to glucose homeostasis disruption

03 Sep 2025

Treatment with antipsychotics may lead to a significant glucose homeostasis dysregulation, regardless of exposure time, dose, diagnosis, and weight gain propensity, according to systematic review and meta-analysis.

Antipsychotic drugs tied to glucose homeostasis disruption

03 Sep 2025

GLP-1 RA use in T2DM may protect against peptic ulcer disease

02 Sep 2025

Patients with type 2 diabetes mellitus (T2DM) who use glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have lower odds of peptic ulcer disease when compared with insulin users, as shown in a retrospective study.

GLP-1 RA use in T2DM may protect against peptic ulcer disease

02 Sep 2025

Irpagratinib plus atezolizumab combo active against FGF19+ HCC

02 Sep 2025 bởi

Combination treatment with the oral, highly selective FGFR4 inhibitor irpagratinib plus atezolizumab has shown promising efficacy in patients with untreated or immune checkpoint inhibitor (ICI)-exposed hepatocellular carcinoma (HCC) with fibroblast growth factor 19 overexpression (FGF19+), while being safe and well tolerated, according to the updated results of the phase II ABSK-011-201 study.

Irpagratinib plus atezolizumab combo active against FGF19+ HCC

02 Sep 2025

Desensitization feasible in patients with HSRs to chemotherapy

02 Sep 2025

Total dose desensitization is successful in patients with hypersensitivity reactions (HSRs) to chemotherapy, suggests a study.

Desensitization feasible in patients with HSRs to chemotherapy

02 Sep 2025

Atezolizumab plus chemo, bevacizumab improves survival in R/M cervical cancer

02 Sep 2025 bởi

The addition of atezolizumab to first-line chemotherapy plus bevacizumab delivers significant improvements in survival among patients with PD-L1+ or PD-L1‒ persistent, recurrent, or metastatic (R/M) cervical cancer, results of a post hoc analysis of the BEATcc study have shown.

Atezolizumab plus chemo, bevacizumab improves survival in R/M cervical cancer

02 Sep 2025

Does aprepitant influence response to DICEP?

02 Sep 2025

A recent study in Canada has shown similar response rates to dose-intensive cyclophosphamide, etoposide, and cisplatin (DICEP) in patients with relapsed/refractory Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL) regardless of aprepitant use.

Does aprepitant influence response to DICEP?

02 Sep 2025

Mislabelled beta-lactam antibiotic allergy linked to post-TKA joint infection, prompts allergy delabelling service

02 Sep 2025 bởi

Patients labelled as allergic to penicillin or other beta-lactam antibiotics face a significantly higher risk of periprosthetic joint infection (PJI) up to 5 years following knee arthroplasty, and should be prioritized for preoperative allergy assessment, researchers from the University of Hong Kong (HKU) have found.

Mislabelled beta-lactam antibiotic allergy linked to post-TKA joint infection, prompts allergy delabelling service

02 Sep 2025

Uveitis risk reduced with GLP-1RAs

01 Sep 2025

Users of glucagon-like peptide-1 receptor agonists (GLP-1RAs) are at lower risk of uveitis compared with nonusers, according to a retrospective study.

Uveitis risk reduced with GLP-1RAs

01 Sep 2025

Pembrolizumab prolongs real-world survival in NSCLC patients

01 Sep 2025

Treatment with pembrolizumab demonstrates effectiveness in improving progression-free survival (PFS) and overall survival (OS) in real clinical practice, results of a study have shown.

Pembrolizumab prolongs real-world survival in NSCLC patients

01 Sep 2025

CYP3A5-guided tacrolimus dosing tied to faster achievement of target trough levels in kidney recipients

01 Sep 2025 bởi

The local ethnic population of kidney transplant recipients in Singapore has a diverse CYP3A5 genotype expression, according to a study. A CYP3A5-guided dosing of tacrolimus may help these patients achieve target trough levels at a faster rate, but it can also put them at greater risk of hyperkalaemia.

CYP3A5-guided tacrolimus dosing tied to faster achievement of target trough levels in kidney recipients

01 Sep 2025

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Antipsychotic drugs tied to glucose homeostasis disruption

Antipsychotic drugs tied to glucose homeostasis disruption

GLP-1 RA use in T2DM may protect against peptic ulcer disease

GLP-1 RA use in T2DM may protect against peptic ulcer disease

Irpagratinib plus atezolizumab combo active against FGF19+ HCC

Irpagratinib plus atezolizumab combo active against FGF19+ HCC

Desensitization feasible in patients with HSRs to chemotherapy

Desensitization feasible in patients with HSRs to chemotherapy

Atezolizumab plus chemo, bevacizumab improves survival in R/M cervical cancer

Atezolizumab plus chemo, bevacizumab improves survival in R/M cervical cancer

Does aprepitant influence response to DICEP?

Does aprepitant influence response to DICEP?

Mislabelled beta-lactam antibiotic allergy linked to post-TKA joint infection, prompts allergy delabelling service

Mislabelled beta-lactam antibiotic allergy linked to post-TKA joint infection, prompts allergy delabelling service

Uveitis risk reduced with GLP-1RAs

Uveitis risk reduced with GLP-1RAs

Pembrolizumab prolongs real-world survival in NSCLC patients

Pembrolizumab prolongs real-world survival in NSCLC patients

CYP3A5-guided tacrolimus dosing tied to faster achievement of target trough levels in kidney recipients

CYP3A5-guided tacrolimus dosing tied to faster achievement of target trough levels in kidney recipients