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Progression-free (PFS) and overall survival (OS) are similar between age groups (≥70 and <70 years) among patients treated with cyclin-dependent kinase (CDK) 4/6 inhibitors from 2015 to 2019, with no significant differences in neutropaenia or thrombocytopaenia toxicity, reports a study.

Starting dose of CDK4/6 inhibitors linked to survival in metastatic breast cancer

Screen time may affect brain development in early childhood

In preschool-aged children, higher digital media use (screen time) was associated with lower cortical thickness (CT) and sulcal depth (SD), according to a secondary analysis of data collated for an MRI-based study.

Screen time may affect brain development in early childhood

Physical activity helps prevent dementia, cognitive impairment in women

Walking daily and performing moderate-to-vigorous physical activity can help lower the risk of mild cognitive impairment (MCI) or dementia in ageing women, as shown in a study.

Physical activity helps prevent dementia, cognitive impairment in women

30 Jan 2023

Prediabetes in youngsters linked to a nearly 80 percent increased risk of CVD

Prediabetes in youngsters is associated with an 88 percent lifetime risk of diabetes and a nearly 80 percent higher risk of cardiovascular disease (CVD), researchers from the Chinese University of Hong Kong (CUHK) have reported.

Prediabetes in youngsters linked to a nearly 80 percent increased risk of CVD

30 Jan 2023

Acupuncture safe, feasible in irritable bowel syndrome

Acupuncture appears to yield significant improvements in irritable bowel syndrome with diarrhoea (IBS-D), a study has found.

Acupuncture safe, feasible in irritable bowel syndrome

30 Jan 2023

Torsemide, furosemide yield similar survival outcomes in heart failure

Treatment with torsemide in survivors of heart failure hospitalization appears to have a similar effect on all-cause mortality over 12 months as furosemide, according to data from the open-label TRANSFORM-HF study.

Torsemide, furosemide yield similar survival outcomes in heart failure

Obesity common among children with medical complexity

Children with medical complexity (CMC) are significantly more likely to be overweight or obese compared with children without chronic medical conditions, according to a recent study.

Obesity common among children with medical complexity

Switching from ARB, ACEI to sacubitril/valsartan ups angioedema risk

New users of sacubitril-valsartan (SV) show no increased risk of angioedema when compared to users of angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB), reports a study.

Switching from ARB, ACEI to sacubitril/valsartan ups angioedema risk

Early-onset fever tied to severe cytokine release syndrome, multiple tocilizumab doses

An earlier onset of fever appears to predict a more severe and progressive cytokine release syndrome, a life-threatening hyper-inflammatory state caused by immune effector cell therapy, suggests a study. Such condition also warrants several doses of anti-interleukin (IL)-6 therapy, such as tocilizumab.

Early-onset fever tied to severe cytokine release syndrome, multiple tocilizumab doses

Ospemifene improves vaginal microbiome of women with vulvovaginal atrophy

Women with vulvovaginal atrophy exhibit a less favourable vaginal microbiome than healthy postmenopausal women, but ospemifene may restore vaginal health by reducing potentially harmful bacteria, as shown in a study.

Ospemifene improves vaginal microbiome of women with vulvovaginal atrophy