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Too much of the good cholesterol can be bad for the brain

06 Dec 2023 bởi

Very high levels of high-density lipoprotein cholesterol (HDL-C) appear to contribute to increased risk of developing dementia among healthy older adults, as reported in a study.

Too much of the good cholesterol can be bad for the brain

06 Dec 2023

LIBRETTO-431: Selpercatinib as 1L SoC for RET fusion–positive NSCLC

05 Dec 2023 bởi

Selpercatinib, a selective RET kinase inhibitor, showed superior efficacy vs chemotherapy and pembrolizumab as first-line (1L) treatment in patients with stage IIIB–IV nonsquamous non-small-cell lung cancer (NSCLC) with RET gene fusions, according to results of the open-label phase III LIBRETTO-431 study presented at the European Society for Medical Oncology Congress 2023 (ESMO 2023).

LIBRETTO-431: Selpercatinib as 1L SoC for RET fusion–positive NSCLC

05 Dec 2023

Transcutaneous neuromodulation improves symptoms in functional dyspepsia

29 Nov 2023

Patients with functional dyspepsia (FD) may benefit from transcutaneous neuromodulation (TN) treatment, which can significantly improve symptoms and quality of life, according to a study.

Transcutaneous neuromodulation improves symptoms in functional dyspepsia

29 Nov 2023

Givosiran delivers safe, sustained improvements in acute hepatic porphyria

28 Nov 2023 bởi

Long-term monthly treatment with givosiran has good tolerability and offers continuous improvements to patients with acute hepatic porphyria (AHP), results of the phase III ENVISION trial have shown.

Givosiran delivers safe, sustained improvements in acute hepatic porphyria

28 Nov 2023

Intracranial atherosclerosis disease linked to cognitive impairment, dementia

28 Nov 2023

Individuals with intracranial atherosclerosis disease (ICAD) have a heightened risk of cognitive impairment and dementia, according to the results of a systematic review and meta-analysis.

Intracranial atherosclerosis disease linked to cognitive impairment, dementia

28 Nov 2023

Zoledronate improves BMD of children with cerebral palsy

23 Nov 2023

Twelve-month treatment with zoledronate significantly increases bone mineral density (BMD) Z-scores without affecting growth in nonambulant children with cerebral palsy (CP), reports a study. However, side effects of the first dose are common.

Zoledronate improves BMD of children with cerebral palsy

23 Nov 2023

Dementia risk heightened after stopping metformin treatment

18 Nov 2023 bởi

Metformin treatment discontinuation has been found to lead to increased incidence of dementia among older adults, and this association cannot be explained by changes in glucose control or insulin use.

Dementia risk heightened after stopping metformin treatment

18 Nov 2023

Chronic HBV infection may up risk of intracerebral haemorrhage

17 Nov 2023

Chronic hepatitis B virus (HBV) infection appears to put Chinese adults at higher risk of intracerebral haemorrhage but not other stroke subtypes, as reported in a study.

Chronic HBV infection may up risk of intracerebral haemorrhage

17 Nov 2023

Strawberries may stave off dementia

12 Nov 2023 bởi

Strawberries can potentially contribute to the prevention of dementia, with a small study suggesting that supplementation with whole-fruit strawberry powder helps improve memory in middle-aged adults.

Strawberries may stave off dementia

12 Nov 2023

Lower chance of new stroke with ticagrelor vs clopidogrel in patients without ICAS

11 Nov 2023 bởi

A post hoc analysis of the CHANCE-2 randomized controlled trial (RCT) demonstrates that ticagrelor-aspirin combination therapy is associated with a significantly lower risk of new stroke within 90 days vs the clopidogrel-aspirin combination in Chinese CYP2C19 loss‐of‐function allele carriers with minor stroke or transient ischaemic attack (TIA) without intracranial artery stenosis (ICAS).

Lower chance of new stroke with ticagrelor vs clopidogrel in patients without ICAS

11 Nov 2023

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Too much of the good cholesterol can be bad for the brain

Too much of the good cholesterol can be bad for the brain

LIBRETTO-431: Selpercatinib as 1L SoC for RET fusion–positive NSCLC

LIBRETTO-431: Selpercatinib as 1L SoC for RET fusion–positive NSCLC

Transcutaneous neuromodulation improves symptoms in functional dyspepsia

Transcutaneous neuromodulation improves symptoms in functional dyspepsia

Givosiran delivers safe, sustained improvements in acute hepatic porphyria

Givosiran delivers safe, sustained improvements in acute hepatic porphyria

Intracranial atherosclerosis disease linked to cognitive impairment, dementia

Intracranial atherosclerosis disease linked to cognitive impairment, dementia

Zoledronate improves BMD of children with cerebral palsy

Zoledronate improves BMD of children with cerebral palsy

Dementia risk heightened after stopping metformin treatment

Dementia risk heightened after stopping metformin treatment

Chronic HBV infection may up risk of intracerebral haemorrhage

Chronic HBV infection may up risk of intracerebral haemorrhage

Strawberries may stave off dementia

Strawberries may stave off dementia

Lower chance of new stroke with ticagrelor vs clopidogrel in patients without ICAS

Lower chance of new stroke with ticagrelor vs clopidogrel in patients without ICAS